A novel classification of lung cancer into molecular subtypes.
The remarkably heterogeneous nature of lung cancer has become more apparent over the last decade. In general, advanced lung cancer is an aggressive malignancy with a poor prognosis. The discovery of multiple molecular mechanisms underlying the development, progression, and prognosis of lung cancer, however, has created new opportunities for targeted therapy and improved outcome. In this paper, we define "molecular subtypes" of lung cancer based on specific actionable genetic aberrations. Each subtype is associated with molecular tests that define the subtype and drugs that may potentially treat it. We hope this paper will be a useful guide to clinicians and researchers alike by assisting in therapy decision making and acting as a platform for further study. In this new era of cancer treatment, the 'one-size-fits-all' paradigm is being forcibly pushed aside-allowing for more effective, personalized oncologic care to emerge.
Duke Scholars
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Related Subject Headings
- Signal Transduction
- Proto-Oncogene Proteins c-akt
- Phosphatidylinositol 3-Kinases
- Molecular Typing
- Lung Neoplasms
- Humans
- General Science & Technology
- ErbB Receptors
- Cell Proliferation
- Cell Death
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Signal Transduction
- Proto-Oncogene Proteins c-akt
- Phosphatidylinositol 3-Kinases
- Molecular Typing
- Lung Neoplasms
- Humans
- General Science & Technology
- ErbB Receptors
- Cell Proliferation
- Cell Death