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The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.

Publication ,  Journal Article
Memmott, RM; Dennis, PA
Published in: Clin Cancer Res
January 1, 2010

Lung cancer is the leading cause of cancer-related death in the United States, and 85 to 90% of lung cancer cases are associated with tobacco use. Tobacco components promote lung tumorigenesis through genotoxic effects, as well as through biochemical modulation of signaling pathways such as the Akt/mammalian target of rapamycin (mTOR) pathway that regulates cell proliferation and survival. This review will describe cell surface receptors and other upstream components required for tobacco carcinogen-induced activation of Akt and mTOR. Preclinical studies show that inhibitors of the Akt/mTOR pathway inhibit tumor formation in mouse models of carcinogen-induced lung tumorigenesis. Some of these inhibitors will be highlighted, and their clinical potential for the treatment and prevention of lung cancer will be discussed.

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Published In

Clin Cancer Res

DOI

EISSN

1557-3265

Publication Date

January 1, 2010

Volume

16

Issue

1

Start / End Page

4 / 10

Location

United States

Related Subject Headings

  • TOR Serine-Threonine Kinases
  • Smoking
  • Sirolimus
  • Signal Transduction
  • Rotenone
  • Proto-Oncogene Proteins c-akt
  • Protein Serine-Threonine Kinases
  • Oncology & Carcinogenesis
  • Nicotiana
  • Mice
 

Citation

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Memmott, R. M., & Dennis, P. A. (2010). The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis. Clin Cancer Res, 16(1), 4–10. https://doi.org/10.1158/1078-0432.CCR-09-0234
Memmott, Regan M., and Phillip A. Dennis. “The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.Clin Cancer Res 16, no. 1 (January 1, 2010): 4–10. https://doi.org/10.1158/1078-0432.CCR-09-0234.
Memmott RM, Dennis PA. The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis. Clin Cancer Res. 2010 Jan 1;16(1):4–10.
Memmott, Regan M., and Phillip A. Dennis. “The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.Clin Cancer Res, vol. 16, no. 1, Jan. 2010, pp. 4–10. Pubmed, doi:10.1158/1078-0432.CCR-09-0234.
Memmott RM, Dennis PA. The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis. Clin Cancer Res. 2010 Jan 1;16(1):4–10.

Published In

Clin Cancer Res

DOI

EISSN

1557-3265

Publication Date

January 1, 2010

Volume

16

Issue

1

Start / End Page

4 / 10

Location

United States

Related Subject Headings

  • TOR Serine-Threonine Kinases
  • Smoking
  • Sirolimus
  • Signal Transduction
  • Rotenone
  • Proto-Oncogene Proteins c-akt
  • Protein Serine-Threonine Kinases
  • Oncology & Carcinogenesis
  • Nicotiana
  • Mice