The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.

Journal Article (Journal Article)

Lung cancer is the leading cause of cancer-related death in the United States, and 85 to 90% of lung cancer cases are associated with tobacco use. Tobacco components promote lung tumorigenesis through genotoxic effects, as well as through biochemical modulation of signaling pathways such as the Akt/mammalian target of rapamycin (mTOR) pathway that regulates cell proliferation and survival. This review will describe cell surface receptors and other upstream components required for tobacco carcinogen-induced activation of Akt and mTOR. Preclinical studies show that inhibitors of the Akt/mTOR pathway inhibit tumor formation in mouse models of carcinogen-induced lung tumorigenesis. Some of these inhibitors will be highlighted, and their clinical potential for the treatment and prevention of lung cancer will be discussed.

Full Text

Duke Authors

Cited Authors

  • Memmott, RM; Dennis, PA

Published Date

  • January 1, 2010

Published In

Volume / Issue

  • 16 / 1

Start / End Page

  • 4 - 10

PubMed ID

  • 20028747

Pubmed Central ID

  • PMC2805044

Electronic International Standard Serial Number (EISSN)

  • 1557-3265

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-09-0234

Language

  • eng

Conference Location

  • United States