Nonhuman Primate Optogenetics: Recent Advances and Future Directions.

Journal Article (Journal Article;Review)

Optogenetics is the use of genetically coded, light-gated ion channels or pumps (opsins) for millisecond resolution control of neural activity. By targeting opsin expression to specific cell types and neuronal pathways, optogenetics can expand our understanding of the neural basis of normal and pathological behavior. To maximize the potential of optogenetics to study human cognition and behavior, optogenetics should be applied to the study of nonhuman primates (NHPs). The homology between NHPs and humans makes these animals the best experimental model for understanding human brain function and dysfunction. Moreover, for genetic tools to have translational promise, their use must be demonstrated effectively in large, wild-type animals such as Rhesus macaques. Here, we review recent advances in primate optogenetics. We highlight the technical hurdles that have been cleared, challenges that remain, and summarize how optogenetic experiments are expanding our understanding of primate brain function.

Full Text

Duke Authors

Cited Authors

  • Galvan, A; Stauffer, WR; Acker, L; El-Shamayleh, Y; Inoue, K-I; Ohayon, S; Schmid, MC

Published Date

  • November 8, 2017

Published In

Volume / Issue

  • 37 / 45

Start / End Page

  • 10894 - 10903

PubMed ID

  • 29118219

Pubmed Central ID

  • PMC5678022

Electronic International Standard Serial Number (EISSN)

  • 1529-2401

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.1839-17.2017

Language

  • eng

Conference Location

  • United States