New methods facilitated the process of prioritizing questions and health outcomes in guideline development.

Journal Article (Journal Article)

BACKGROUND: Health guideline development requires sequential prioritization of the guideline topic, questions, and health outcomes. In this paper we report on new approaches for prioritizing questions and outcomes in guidelines. METHODS: Ten guideline panels on venous thromboembolism rated potential guideline questions on a 9-point scale according to their overall importance and 6 criteria: common in practice, uncertainty in practice, variation in practice, new evidence available, cost consequences, not previously addressed. We randomized panelists to rate one potential question with and without the 6 criteria. Panelists rated importance of outcomes, defined with health outcome descriptors (HODs), using a 9-point scale, and health utility of outcomes on a visual analogue scale. RESULTS: Of 469 potential questions identified, 72.5% were rated as important but not of high priority, and 25.4% as high priority. Each criterion was significantly associated with the overall importance rating. The overall importance rating means were 5.96 (SD 2.38) and 6.53 (SD 2.45) (P = 0.25) for those randomized to rate questions with and without the criteria, respectively. The mean importance rating for 121 outcomes was 6.01 (SD 1.25), with 35.5% rated as critical for decision-making. Panelists provided health utility ratings for 127 outcomes, with a minimum mean rating of 0.12 (SD 0.10) and maximum of 0.91 (SD 0.15). CONCLUSION: Our structured process provided information to help explain perspectives of question importance, to facilitate panels' outcome prioritization, and to facilitate decision-making in guideline development.

Full Text

Duke Authors

Cited Authors

  • Wiercioch, W; Nieuwlaat, R; Zhang, Y; Alonso-Coello, P; Dahm, P; Iorio, A; Manja, V; Mustafa, RA; Neumann, I; Ortel, TL; Rochwerg, B; Santesso, N; Vesely, SK; Akl, EA; Schünemann, HJ

Published Date

  • March 2022

Published In

Volume / Issue

  • 143 /

Start / End Page

  • 91 - 104

PubMed ID

  • 34843861

Electronic International Standard Serial Number (EISSN)

  • 1878-5921

Digital Object Identifier (DOI)

  • 10.1016/j.jclinepi.2021.11.031

Language

  • eng

Conference Location

  • United States