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Association of sleep and circadian patterns and genetic risk with incident type 2 diabetes: a large prospective population-based cohort study.

Publication ,  Journal Article
Li, Z-H; Zhang, P-D; Chen, Q; Gao, X; Chung, VCH; Shen, D; Zhang, X-R; Zhong, W-F; Huang, Q-M; Liu, D; Chen, P-L; Song, W-Q; Wu, X-B; Mao, C ...
Published in: Eur J Endocrinol
October 19, 2021

OBJECTIVE: To examine the association of incident type 2 diabetes (T2D) risk with sleep factors, genetic risk, and their combination effects. DESIGN: Large prospective population-based cohort study. METHODS: This population-based prospective cohort study included 360 403 (mean (s.d.) age: 56.6 (8.0) years) participants without T2D at baseline from the UK Biobank. Genetic risk was categorised as high (highest quintile), intermediate (quintiles: 2-4), and low (lowest quintile) based on a polygenic risk score for T2D. Sleep scores, including long or short sleep duration, insomnia, snoring, late chronotype, and excessive daytime sleepiness, were categorized as an unfavourable, intermediate, or favourable sleep and circadian pattern. RESULTS: During a median follow-up of 9.0 years, 13 120 incident T2D cases were recorded. Among the participants with an unfavourable sleep and circadian pattern, 6.96% (95% CI: 6.68-7.24%) developed T2D vs 2.37% (95% CI: 2.28-2.46%) of participants with a favourable sleep and circadian pattern (adjusted hazard ratio (HR): 1.53, 95% CI: 1.45-1.62). Of participants with a high genetic risk, 5.53% (95% CI: 5.36-5.69%) developed T2D vs 2.01% (95% CI: 1.91-2.11%) of participants with a low genetic risk (adjusted HR: 2.89, 95% CI: 2.72-3.07). The association with sleep and circadian patterns was independent of genetic risk strata. Participants in the lowest quintile with an unfavourable sleep and circadian pattern were 3.97-fold more likely to develop T2D than those in the lowest quintile with a favourable sleep and circadian pattern. CONCLUSIONS: Sleep and circadian patterns and genetic risk were independently associated with incident T2D. These results indicate the benefits of adhering to a healthy sleep and circadian pattern in entire populations, independent of genetic risk.

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Published In

Eur J Endocrinol

DOI

EISSN

1479-683X

Publication Date

October 19, 2021

Volume

185

Issue

5

Start / End Page

765 / 774

Location

England

Related Subject Headings

  • Sleep Wake Disorders
  • Sleep
  • Prospective Studies
  • Population Surveillance
  • Middle Aged
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Follow-Up Studies
  • Female
 

Citation

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ICMJE
MLA
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Li, Z.-H., Zhang, P.-D., Chen, Q., Gao, X., Chung, V. C. H., Shen, D., … Mao, C. (2021). Association of sleep and circadian patterns and genetic risk with incident type 2 diabetes: a large prospective population-based cohort study. Eur J Endocrinol, 185(5), 765–774. https://doi.org/10.1530/EJE-21-0314
Li, Zhi-Hao, Pei-Dong Zhang, Qing Chen, Xiang Gao, Vincent C. H. Chung, Dong Shen, Xi-Ru Zhang, et al. “Association of sleep and circadian patterns and genetic risk with incident type 2 diabetes: a large prospective population-based cohort study.Eur J Endocrinol 185, no. 5 (October 19, 2021): 765–74. https://doi.org/10.1530/EJE-21-0314.
Li Z-H, Zhang P-D, Chen Q, Gao X, Chung VCH, Shen D, et al. Association of sleep and circadian patterns and genetic risk with incident type 2 diabetes: a large prospective population-based cohort study. Eur J Endocrinol. 2021 Oct 19;185(5):765–74.
Li, Zhi-Hao, et al. “Association of sleep and circadian patterns and genetic risk with incident type 2 diabetes: a large prospective population-based cohort study.Eur J Endocrinol, vol. 185, no. 5, Oct. 2021, pp. 765–74. Pubmed, doi:10.1530/EJE-21-0314.
Li Z-H, Zhang P-D, Chen Q, Gao X, Chung VCH, Shen D, Zhang X-R, Zhong W-F, Huang Q-M, Liu D, Chen P-L, Song W-Q, Wu X-B, Byers Kraus V, Mao C. Association of sleep and circadian patterns and genetic risk with incident type 2 diabetes: a large prospective population-based cohort study. Eur J Endocrinol. 2021 Oct 19;185(5):765–774.

Published In

Eur J Endocrinol

DOI

EISSN

1479-683X

Publication Date

October 19, 2021

Volume

185

Issue

5

Start / End Page

765 / 774

Location

England

Related Subject Headings

  • Sleep Wake Disorders
  • Sleep
  • Prospective Studies
  • Population Surveillance
  • Middle Aged
  • Male
  • Humans
  • Genetic Predisposition to Disease
  • Follow-Up Studies
  • Female