The Pathobiology of Pulmonary Arterial Hypertension.
Publication
, Journal Article
Rajagopal, S; Yu, Y-RA
Published in: Cardiol Clin
February 2022
Pulmonary arterial hypertension is characterized by obliteration and obstruction of the pulmonary arterioles that in turn results in high right ventricular afterload and right heart failure. The pathobiology of pulmonary arterial hypertension is complex, with contributions from multiple pathophysiologic processes that are regulated by a variety of molecular mechanisms. This nature likely explains the limited efficacy of our current therapies, which only target a small portion of the pathobiological mechanisms that underlie advanced disease. Here we review the pathobiology of pulmonary arterial hypertension, focusing on the systemic, cellular, and molecular mechanisms that underlie the disease.
Duke Scholars
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Published In
Cardiol Clin
DOI
EISSN
1558-2264
Publication Date
February 2022
Volume
40
Issue
1
Start / End Page
1 / 12
Location
Netherlands
Related Subject Headings
- Pulmonary Artery
- Pulmonary Arterial Hypertension
- Hypertension, Pulmonary
- Humans
- Heart Ventricles
- Heart Failure
- Familial Primary Pulmonary Hypertension
- Cardiovascular System & Hematology
- 3201 Cardiovascular medicine and haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Rajagopal, S., & Yu, Y.-R. (2022). The Pathobiology of Pulmonary Arterial Hypertension. Cardiol Clin, 40(1), 1–12. https://doi.org/10.1016/j.ccl.2021.08.001
Rajagopal, Sudarshan, and Yen-Rei A. Yu. “The Pathobiology of Pulmonary Arterial Hypertension.” Cardiol Clin 40, no. 1 (February 2022): 1–12. https://doi.org/10.1016/j.ccl.2021.08.001.
Rajagopal S, Yu Y-RA. The Pathobiology of Pulmonary Arterial Hypertension. Cardiol Clin. 2022 Feb;40(1):1–12.
Rajagopal, Sudarshan, and Yen-Rei A. Yu. “The Pathobiology of Pulmonary Arterial Hypertension.” Cardiol Clin, vol. 40, no. 1, Feb. 2022, pp. 1–12. Pubmed, doi:10.1016/j.ccl.2021.08.001.
Rajagopal S, Yu Y-RA. The Pathobiology of Pulmonary Arterial Hypertension. Cardiol Clin. 2022 Feb;40(1):1–12.
Published In
Cardiol Clin
DOI
EISSN
1558-2264
Publication Date
February 2022
Volume
40
Issue
1
Start / End Page
1 / 12
Location
Netherlands
Related Subject Headings
- Pulmonary Artery
- Pulmonary Arterial Hypertension
- Hypertension, Pulmonary
- Humans
- Heart Ventricles
- Heart Failure
- Familial Primary Pulmonary Hypertension
- Cardiovascular System & Hematology
- 3201 Cardiovascular medicine and haematology