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The Pathobiology of Pulmonary Arterial Hypertension.

Publication ,  Journal Article
Rajagopal, S; Yu, Y-RA
Published in: Cardiol Clin
February 2022

Pulmonary arterial hypertension is characterized by obliteration and obstruction of the pulmonary arterioles that in turn results in high right ventricular afterload and right heart failure. The pathobiology of pulmonary arterial hypertension is complex, with contributions from multiple pathophysiologic processes that are regulated by a variety of molecular mechanisms. This nature likely explains the limited efficacy of our current therapies, which only target a small portion of the pathobiological mechanisms that underlie advanced disease. Here we review the pathobiology of pulmonary arterial hypertension, focusing on the systemic, cellular, and molecular mechanisms that underlie the disease.

Duke Scholars

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Published In

Cardiol Clin

DOI

EISSN

1558-2264

Publication Date

February 2022

Volume

40

Issue

1

Start / End Page

1 / 12

Location

Netherlands

Related Subject Headings

  • Pulmonary Artery
  • Pulmonary Arterial Hypertension
  • Hypertension, Pulmonary
  • Humans
  • Heart Ventricles
  • Heart Failure
  • Familial Primary Pulmonary Hypertension
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
 

Citation

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ICMJE
MLA
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Rajagopal, S., & Yu, Y.-R. (2022). The Pathobiology of Pulmonary Arterial Hypertension. Cardiol Clin, 40(1), 1–12. https://doi.org/10.1016/j.ccl.2021.08.001
Rajagopal, Sudarshan, and Yen-Rei A. Yu. “The Pathobiology of Pulmonary Arterial Hypertension.Cardiol Clin 40, no. 1 (February 2022): 1–12. https://doi.org/10.1016/j.ccl.2021.08.001.
Rajagopal S, Yu Y-RA. The Pathobiology of Pulmonary Arterial Hypertension. Cardiol Clin. 2022 Feb;40(1):1–12.
Rajagopal, Sudarshan, and Yen-Rei A. Yu. “The Pathobiology of Pulmonary Arterial Hypertension.Cardiol Clin, vol. 40, no. 1, Feb. 2022, pp. 1–12. Pubmed, doi:10.1016/j.ccl.2021.08.001.
Rajagopal S, Yu Y-RA. The Pathobiology of Pulmonary Arterial Hypertension. Cardiol Clin. 2022 Feb;40(1):1–12.
Journal cover image

Published In

Cardiol Clin

DOI

EISSN

1558-2264

Publication Date

February 2022

Volume

40

Issue

1

Start / End Page

1 / 12

Location

Netherlands

Related Subject Headings

  • Pulmonary Artery
  • Pulmonary Arterial Hypertension
  • Hypertension, Pulmonary
  • Humans
  • Heart Ventricles
  • Heart Failure
  • Familial Primary Pulmonary Hypertension
  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology