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Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma.

Publication ,  Journal Article
Rao, SR; Lazarides, AL; Leckey, BL; Lane, WO; Visgauss, JD; Somarelli, JA; Kirsch, DG; Larrier, NA; Brigman, BE; Blazer, DG; Cardona, DM; Eward, WC
Published in: Cancer Med
January 2022

INTRODUCTION: Current standard of care for most intermediate and high-grade soft-tissue sarcomas (STS) includes limb-preserving surgical resection with either neoadjuvant radiation therapy (NRT) or adjuvant radiation therapy. To date, there have been a few studies that attempt to correlate histopathologic response to NRT with oncologic outcomes in patients with STS. METHODS: Using our institutional database, we identified 58 patients who received NRT followed by surgical resection for primary intermediate or high-grade STS and 34 patients who received surgical resection without NRT but did receive adjuvant radiation therapy or did not receive any radiation therapy. We analyzed four histologic parameters of response to therapy: residual viable tumor, fibrosis/hyalinization, necrosis, and infarction (each ratiometrically determined). Data were stratified into two binary groups. Unadjusted, 5- and 10-year overall survival, and relapsed-free survival (RFS) were calculated using the Kaplan-Meier method. RESULTS: Analysis of pathologic characteristics showed that patients treated with NRT demonstrate significantly higher tumor infarction, higher tumor fibrosis/hyalinization, and a lower percent viable tumor compared with patients not treated with NRT (p < 0.0001). Based on Kaplan-Meier curve analysis and multivariate cox proportional hazard model for OS and RFS, patients treated with NRT and showing >12.5% tumor fibrosis/hyalinization have significantly higher overall survival and recurrence-free survival at 5 and 10 years. DISCUSSION AND CONCLUSION: We have identified three histopathologic characteristics-fibrosis, hyalinization, and infarction-that may serve as predictive biomarkers of response to NRT for STS patients. Future prospective studies will be needed to confirm this association.

Duke Scholars

Published In

Cancer Med

DOI

EISSN

2045-7634

Publication Date

January 2022

Volume

11

Issue

1

Start / End Page

194 / 206

Location

United States

Related Subject Headings

  • Sarcoma
  • Retrospective Studies
  • Proportional Hazards Models
  • Neoadjuvant Therapy
  • Necrosis
  • Middle Aged
  • Male
  • Kaplan-Meier Estimate
  • Infarction
  • Hyalin
 

Citation

APA
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MLA
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Rao, S. R., Lazarides, A. L., Leckey, B. L., Lane, W. O., Visgauss, J. D., Somarelli, J. A., … Eward, W. C. (2022). Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma. Cancer Med, 11(1), 194–206. https://doi.org/10.1002/cam4.4428
Rao, Sneha R., Alexander L. Lazarides, Bruce L. Leckey, Whitney O. Lane, Julia D. Visgauss, Jason A. Somarelli, David G. Kirsch, et al. “Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma.Cancer Med 11, no. 1 (January 2022): 194–206. https://doi.org/10.1002/cam4.4428.
Rao SR, Lazarides AL, Leckey BL, Lane WO, Visgauss JD, Somarelli JA, et al. Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma. Cancer Med. 2022 Jan;11(1):194–206.
Rao, Sneha R., et al. “Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma.Cancer Med, vol. 11, no. 1, Jan. 2022, pp. 194–206. Pubmed, doi:10.1002/cam4.4428.
Rao SR, Lazarides AL, Leckey BL, Lane WO, Visgauss JD, Somarelli JA, Kirsch DG, Larrier NA, Brigman BE, Blazer DG, Cardona DM, Eward WC. Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma. Cancer Med. 2022 Jan;11(1):194–206.
Journal cover image

Published In

Cancer Med

DOI

EISSN

2045-7634

Publication Date

January 2022

Volume

11

Issue

1

Start / End Page

194 / 206

Location

United States

Related Subject Headings

  • Sarcoma
  • Retrospective Studies
  • Proportional Hazards Models
  • Neoadjuvant Therapy
  • Necrosis
  • Middle Aged
  • Male
  • Kaplan-Meier Estimate
  • Infarction
  • Hyalin