Pulmonary Hypertension in Adults with Congenital Heart Disease.
Publication
, Journal Article
Goldstein, SA; Krasuski, RA
Published in: Cardiol Clin
February 2022
Pulmonary arterial hypertension related to congenital heart disease (PAH-CHD) affects 5% to 10% of adults with CHD and is associated with significant morbidity and mortality. PAH-CHD develops as a consequence of intracardiac or extracardiac systemic-to-pulmonary shunts that lead to pulmonary vascular remodeling through a pathologic process that is similar to other causes of PAH. Eisenmenger syndrome is the most severe phenotype of PAH-CHD and is characterized by severe elevation in pulmonary vascular resistance, with shunt reversal causing hypoxemia and central cyanosis. The primary management strategy for most patients with PAH-CHD is medical therapy, although defect closure is considered in select cases.
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Published In
Cardiol Clin
DOI
EISSN
1558-2264
Publication Date
February 2022
Volume
40
Issue
1
Start / End Page
55 / 67
Location
Netherlands
Related Subject Headings
- Hypertension, Pulmonary
- Humans
- Heart Defects, Congenital
- Heart
- Eisenmenger Complex
- Cardiovascular System & Hematology
- Adult
- 3201 Cardiovascular medicine and haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Goldstein, S. A., & Krasuski, R. A. (2022). Pulmonary Hypertension in Adults with Congenital Heart Disease. Cardiol Clin, 40(1), 55–67. https://doi.org/10.1016/j.ccl.2021.08.006
Goldstein, Sarah A., and Richard A. Krasuski. “Pulmonary Hypertension in Adults with Congenital Heart Disease.” Cardiol Clin 40, no. 1 (February 2022): 55–67. https://doi.org/10.1016/j.ccl.2021.08.006.
Goldstein SA, Krasuski RA. Pulmonary Hypertension in Adults with Congenital Heart Disease. Cardiol Clin. 2022 Feb;40(1):55–67.
Goldstein, Sarah A., and Richard A. Krasuski. “Pulmonary Hypertension in Adults with Congenital Heart Disease.” Cardiol Clin, vol. 40, no. 1, Feb. 2022, pp. 55–67. Pubmed, doi:10.1016/j.ccl.2021.08.006.
Goldstein SA, Krasuski RA. Pulmonary Hypertension in Adults with Congenital Heart Disease. Cardiol Clin. 2022 Feb;40(1):55–67.
Published In
Cardiol Clin
DOI
EISSN
1558-2264
Publication Date
February 2022
Volume
40
Issue
1
Start / End Page
55 / 67
Location
Netherlands
Related Subject Headings
- Hypertension, Pulmonary
- Humans
- Heart Defects, Congenital
- Heart
- Eisenmenger Complex
- Cardiovascular System & Hematology
- Adult
- 3201 Cardiovascular medicine and haematology