Skip to main content
Journal cover image

Pulmonary Hypertension in Adults with Congenital Heart Disease.

Publication ,  Journal Article
Goldstein, SA; Krasuski, RA
Published in: Cardiol Clin
February 2022

Pulmonary arterial hypertension related to congenital heart disease (PAH-CHD) affects 5% to 10% of adults with CHD and is associated with significant morbidity and mortality. PAH-CHD develops as a consequence of intracardiac or extracardiac systemic-to-pulmonary shunts that lead to pulmonary vascular remodeling through a pathologic process that is similar to other causes of PAH. Eisenmenger syndrome is the most severe phenotype of PAH-CHD and is characterized by severe elevation in pulmonary vascular resistance, with shunt reversal causing hypoxemia and central cyanosis. The primary management strategy for most patients with PAH-CHD is medical therapy, although defect closure is considered in select cases.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cardiol Clin

DOI

EISSN

1558-2264

Publication Date

February 2022

Volume

40

Issue

1

Start / End Page

55 / 67

Location

Netherlands

Related Subject Headings

  • Hypertension, Pulmonary
  • Humans
  • Heart Defects, Congenital
  • Heart
  • Eisenmenger Complex
  • Cardiovascular System & Hematology
  • Adult
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Goldstein, S. A., & Krasuski, R. A. (2022). Pulmonary Hypertension in Adults with Congenital Heart Disease. Cardiol Clin, 40(1), 55–67. https://doi.org/10.1016/j.ccl.2021.08.006
Goldstein, Sarah A., and Richard A. Krasuski. “Pulmonary Hypertension in Adults with Congenital Heart Disease.Cardiol Clin 40, no. 1 (February 2022): 55–67. https://doi.org/10.1016/j.ccl.2021.08.006.
Goldstein SA, Krasuski RA. Pulmonary Hypertension in Adults with Congenital Heart Disease. Cardiol Clin. 2022 Feb;40(1):55–67.
Goldstein, Sarah A., and Richard A. Krasuski. “Pulmonary Hypertension in Adults with Congenital Heart Disease.Cardiol Clin, vol. 40, no. 1, Feb. 2022, pp. 55–67. Pubmed, doi:10.1016/j.ccl.2021.08.006.
Goldstein SA, Krasuski RA. Pulmonary Hypertension in Adults with Congenital Heart Disease. Cardiol Clin. 2022 Feb;40(1):55–67.
Journal cover image

Published In

Cardiol Clin

DOI

EISSN

1558-2264

Publication Date

February 2022

Volume

40

Issue

1

Start / End Page

55 / 67

Location

Netherlands

Related Subject Headings

  • Hypertension, Pulmonary
  • Humans
  • Heart Defects, Congenital
  • Heart
  • Eisenmenger Complex
  • Cardiovascular System & Hematology
  • Adult
  • 3201 Cardiovascular medicine and haematology