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Coagulation Abnormalities and Clinical Complications in Children With SARS-CoV-2: A Systematic Review of 48,322 Patients.

Publication ,  Journal Article
McDaniel, CG; Commander, SJ; DeLaura, I; Cantrell, S; Leraas, HJ; Moore, CB; Reed, CR; Pahl, KS; Tracy, ET
Published in: J Pediatr Hematol Oncol
August 1, 2022

Given the limited information on the coagulation abnormalities of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pediatric patients, we designed a systematic review to evaluate this topic. A comprehensive literature search was conducted for "SARS-CoV-2," "coagulopathy," and "pediatrics." Two authors independently screened the articles that the search returned for bleeding, thrombosis, anticoagulant and/or antiplatelet usage, and abnormal laboratory markers in pediatric patients with SARS-CoV-2, and the authors then extracted the relevant data. One hundred twenty-six publications were included. Thirty-four (27%) studies reported thrombotic complications in 504 patients. Thirty-one (25%) studies reported bleeding complications in 410 patients. Ninety-eight (78%) studies reported abnormal laboratory values in 6580 patients. Finally, 56 (44%) studies reported anticoagulant and/or antiplatelet usage in 3124 patients. The variety of laboratory abnormalities and coagulation complications associated with SARS-CoV-2 presented in this review highlights the complexity and variability of the disease presentation in infants and children.

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Published In

J Pediatr Hematol Oncol

DOI

EISSN

1536-3678

Publication Date

August 1, 2022

Volume

44

Issue

6

Start / End Page

323 / 335

Location

United States

Related Subject Headings

  • Thrombosis
  • SARS-CoV-2
  • Oncology & Carcinogenesis
  • Infant
  • Humans
  • Child
  • COVID-19
  • Blood Coagulation Disorders
  • Anticoagulants
  • 3201 Cardiovascular medicine and haematology
 

Citation

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McDaniel, C. G., Commander, S. J., DeLaura, I., Cantrell, S., Leraas, H. J., Moore, C. B., … Tracy, E. T. (2022). Coagulation Abnormalities and Clinical Complications in Children With SARS-CoV-2: A Systematic Review of 48,322 Patients. J Pediatr Hematol Oncol, 44(6), 323–335. https://doi.org/10.1097/MPH.0000000000002321
McDaniel, Charles Griffin, Sarah J. Commander, Isabel DeLaura, Sarah Cantrell, Harold J. Leraas, Carrie B. Moore, Christopher R. Reed, Kristy S. Pahl, and Elisabeth T. Tracy. “Coagulation Abnormalities and Clinical Complications in Children With SARS-CoV-2: A Systematic Review of 48,322 Patients.J Pediatr Hematol Oncol 44, no. 6 (August 1, 2022): 323–35. https://doi.org/10.1097/MPH.0000000000002321.
McDaniel CG, Commander SJ, DeLaura I, Cantrell S, Leraas HJ, Moore CB, et al. Coagulation Abnormalities and Clinical Complications in Children With SARS-CoV-2: A Systematic Review of 48,322 Patients. J Pediatr Hematol Oncol. 2022 Aug 1;44(6):323–35.
McDaniel, Charles Griffin, et al. “Coagulation Abnormalities and Clinical Complications in Children With SARS-CoV-2: A Systematic Review of 48,322 Patients.J Pediatr Hematol Oncol, vol. 44, no. 6, Aug. 2022, pp. 323–35. Pubmed, doi:10.1097/MPH.0000000000002321.
McDaniel CG, Commander SJ, DeLaura I, Cantrell S, Leraas HJ, Moore CB, Reed CR, Pahl KS, Tracy ET. Coagulation Abnormalities and Clinical Complications in Children With SARS-CoV-2: A Systematic Review of 48,322 Patients. J Pediatr Hematol Oncol. 2022 Aug 1;44(6):323–335.

Published In

J Pediatr Hematol Oncol

DOI

EISSN

1536-3678

Publication Date

August 1, 2022

Volume

44

Issue

6

Start / End Page

323 / 335

Location

United States

Related Subject Headings

  • Thrombosis
  • SARS-CoV-2
  • Oncology & Carcinogenesis
  • Infant
  • Humans
  • Child
  • COVID-19
  • Blood Coagulation Disorders
  • Anticoagulants
  • 3201 Cardiovascular medicine and haematology