Advances in the management of breast cancer brain metastases.

Journal Article (Review;Journal Article)

The development of breast cancer (BC) brain metastases (BrM) is a common complication of advanced disease, occurring in up to half of the patients with advanced disease depending on the subtype. The management of BCBrM requires complex multidisciplinary care including local therapy, surgical resection and/or radiotherapy, palliative care, and carefully selected systemic therapies. Significant progress has been made in the human epidermal growth factor receptor 2-positive (HER2+) BCBrM population due to novel brain penetrable systemic therapies. Increased inclusion of patients with BCBrM in clinical trials using brain-penetrant systemic therapies recently led to the first FDA approval of a HER2-directed therapy specifically in the BCBrM population in the last year. Advances for the treatment of HR+/HER2- and TNBC BCBrM subgroups continue to evolve. In this review, we will discuss the diagnosis and multidisciplinary care of BCBrM. We focus on recent advances in neurosurgery, radiation therapy, and systemic treatment therapies with intracranial activity. We also provide an overview of the current clinical trial landscape for patients with BCBrM.

Full Text

Duke Authors

Cited Authors

  • Sammons, S; Van Swearingen, AED; Chung, C; Anders, CK

Published Date

  • November 2021

Published In

Volume / Issue

  • 3 / Suppl 5

Start / End Page

  • v63 - v74

PubMed ID

  • 34859234

Pubmed Central ID

  • PMC8633750

Electronic International Standard Serial Number (EISSN)

  • 2632-2498

International Standard Serial Number (ISSN)

  • 2632-2498

Digital Object Identifier (DOI)

  • 10.1093/noajnl/vdab119


  • eng