Genetic Testing for Heritable Cardiovascular Diseases in Pediatric Patients: A Scientific Statement From the American Heart Association.

Journal Article (Journal Article)

Genetic diseases that affect the cardiovascular system are relatively common and include cardiac channelopathies, cardiomyopathies, aortopathies, hypercholesterolemias, and structural diseases of the heart and great vessels. The rapidly expanding availability of clinical genetic testing leverages decades of research into the genetic origins of these diseases, helping inform diagnosis, clinical management, and prognosis. Although a number of guidelines and statements detail best practices for cardiovascular genetic testing, there is a paucity of pediatric-focused statements addressing the unique challenges in testing in this vulnerable population. In this scientific statement, we seek to coalesce the existing literature around the use of genetic testing for cardiovascular disease in infants, children, and adolescents.

Full Text

Duke Authors

Cited Authors

  • Landstrom, AP; Kim, JJ; Gelb, BD; Helm, BM; Kannankeril, PJ; Semsarian, C; Sturm, AC; Tristani-Firouzi, M; Ware, SM; American Heart Association Council on Genomic and Precision Medicine; Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Council on Lifestyle and Cardiometabolic Health,

Published Date

  • October 2021

Published In

Volume / Issue

  • 14 / 5

Start / End Page

  • e000086 -

PubMed ID

  • 34412507

Pubmed Central ID

  • PMC8546375

Electronic International Standard Serial Number (EISSN)

  • 2574-8300

Digital Object Identifier (DOI)

  • 10.1161/HCG.0000000000000086


  • eng

Conference Location

  • United States