Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases.

Journal Article (Journal Article;Review)

The transmembrane protein 16 (TMEM16) family consists of Ca2+-activated ion channels and Ca2+-activated phospholipid scramblases (CaPLSases) that passively flip-flop phospholipids between the two leaflets of the membrane bilayer. Owing to their diverse functions, TMEM16 proteins have been implicated in various human diseases, including asthma, cancer, bleeding disorders, muscular dystrophy, arthritis, epilepsy, dystonia, ataxia, and viral infection. To understand TMEM16 proteins in health and disease, it is critical to decipher their molecular mechanisms of activation gating and regulation. Structural, biophysical, and computational characterizations over the past decade have greatly advanced the molecular understanding of TMEM16 proteins. In this review, we summarize major structural features of the TMEM16 proteins with a focus on regulatory mechanisms and gating.

Full Text

Duke Authors

Cited Authors

  • Le, SC; Liang, P; Lowry, AJ; Yang, H

Published Date

  • 2021

Published In

Volume / Issue

  • 12 /

Start / End Page

  • 787773 -

PubMed ID

  • 34867487

Pubmed Central ID

  • PMC8640346

International Standard Serial Number (ISSN)

  • 1664-042X

Digital Object Identifier (DOI)

  • 10.3389/fphys.2021.787773


  • eng

Conference Location

  • Switzerland