From induction to conduction: how intrinsic transcriptional priming of extrinsic neuronal connectivity shapes neuronal identity.

Journal Article (Review;Journal Article)

Every behaviour of an organism relies on an intricate and vastly diverse network of neurons whose identity and connectivity must be specified with extreme precision during development. Intrinsically, specification of neuronal identity depends heavily on the expression of powerful transcription factors that direct numerous features of neuronal identity, including especially properties of neuronal connectivity, such as dendritic morphology, axonal targeting or synaptic specificity, ultimately priming the neuron for incorporation into emerging circuitry. As the neuron's early connectivity is established, extrinsic signals from its pre- and postsynaptic partners feedback on the neuron to further refine its unique characteristics. As a result, disruption of one component of the circuitry during development can have vital consequences for the proper identity specification of its synaptic partners. Recent studies have begun to harness the power of various transcription factors that control neuronal cell fate, including those that specify a neuron's subtype-specific identity, seeking insight for future therapeutic strategies that aim to reconstitute damaged circuitry through neuronal reprogramming.

Full Text

Duke Authors

Cited Authors

  • Russ, JB; Kaltschmidt, JA

Published Date

  • October 2014

Published In

Volume / Issue

  • 4 / 10

Start / End Page

  • 140144 -

PubMed ID

  • 25297387

Pubmed Central ID

  • PMC4221895

Electronic International Standard Serial Number (EISSN)

  • 2046-2441

International Standard Serial Number (ISSN)

  • 2046-2441

Digital Object Identifier (DOI)

  • 10.1098/rsob.140144


  • eng