Invasive fungal infections in neonates: a review.

Journal Article (Journal Article;Review)

Invasive fungal infections remain the leading causes of morbidity and mortality in neonates, especially preterm and very low birth weight infants. Most invasive fungal infections are due to Candida or Aspergillus species, and other fungi are increasingly reported and described. Appropriate identification and treatment are required to augment activity and reduce the toxicity of antifungal drugs. Successful use of antifungals in the vulnerable neonatal population is important for both prevention and treatment of infection. Strategies for prevention, including prophylactic antifungal therapy as well as reducing exposure to modifiable risk factors, like limiting antibiotic exposure, discontinuation of central catheters, and hand hygiene are key techniques to prevent and decrease rates of invasive fungal infections. In conclusion, this is a review of the most common causes, prevention strategies, prophylaxis, and treatment of invasive fungal infections in neonates.

Full Text

Duke Authors

Cited Authors

  • Weimer, KED; Smith, PB; Puia-Dumitrescu, M; Aleem, S

Published Date

  • January 2022

Published In

Volume / Issue

  • 91 / 2

Start / End Page

  • 404 - 412

PubMed ID

  • 34880444

Electronic International Standard Serial Number (EISSN)

  • 1530-0447

Digital Object Identifier (DOI)

  • 10.1038/s41390-021-01842-7

Language

  • eng

Conference Location

  • United States