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Sickness and the Social Brain: How the Immune System Regulates Behavior across Species.

Publication ,  Journal Article
Devlin, BA; Smith, CJ; Bilbo, SD
Published in: Brain, behavior and evolution
January 2022

Many instances of sickness critically involve the immune system. The immune system talks to the brain in a bidirectional loop. This discourse affords the immune system immense control, such that it can influence behavior and optimize recovery from illness. These behavioral responses to infection are called sickness behaviors and can manifest in many ways, including changes in mood, motivation, or energy. Fascinatingly, most of these changes are conserved across species, and most organisms demonstrate some form of sickness behaviors. One of the most interesting sickness behaviors, and not immediately obvious, is altered sociability. Here, we discuss how the immune system impacts social behavior, by examining the brain regions and immune mediators involved in this process. We first outline how social behavior changes in response to infection in various species. Next, we explore which brain regions control social behavior and their evolutionary origins. Finally, we describe which immune mediators establish the link between illness and social behavior, in the context of both normal development and infection. Overall, we hope to make clear the striking similarities between the mechanisms that facilitate changes in sociability in derived and ancestral vertebrate, as well as invertebrate, species.

Duke Scholars

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Published In

Brain, behavior and evolution

DOI

EISSN

1421-9743

ISSN

0006-8977

Publication Date

January 2022

Volume

97

Issue

3-4

Start / End Page

197 / 210

Related Subject Headings

  • Social Behavior
  • Neurology & Neurosurgery
  • Immune System
  • Illness Behavior
  • Brain
  • Animals
  • 52 Psychology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
 

Citation

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ICMJE
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Devlin, B. A., Smith, C. J., & Bilbo, S. D. (2022). Sickness and the Social Brain: How the Immune System Regulates Behavior across Species. Brain, Behavior and Evolution, 97(3–4), 197–210. https://doi.org/10.1159/000521476
Devlin, Benjamin A., Caroline J. Smith, and Staci D. Bilbo. “Sickness and the Social Brain: How the Immune System Regulates Behavior across Species.Brain, Behavior and Evolution 97, no. 3–4 (January 2022): 197–210. https://doi.org/10.1159/000521476.
Devlin BA, Smith CJ, Bilbo SD. Sickness and the Social Brain: How the Immune System Regulates Behavior across Species. Brain, behavior and evolution. 2022 Jan;97(3–4):197–210.
Devlin, Benjamin A., et al. “Sickness and the Social Brain: How the Immune System Regulates Behavior across Species.Brain, Behavior and Evolution, vol. 97, no. 3–4, Jan. 2022, pp. 197–210. Epmc, doi:10.1159/000521476.
Devlin BA, Smith CJ, Bilbo SD. Sickness and the Social Brain: How the Immune System Regulates Behavior across Species. Brain, behavior and evolution. 2022 Jan;97(3–4):197–210.
Journal cover image

Published In

Brain, behavior and evolution

DOI

EISSN

1421-9743

ISSN

0006-8977

Publication Date

January 2022

Volume

97

Issue

3-4

Start / End Page

197 / 210

Related Subject Headings

  • Social Behavior
  • Neurology & Neurosurgery
  • Immune System
  • Illness Behavior
  • Brain
  • Animals
  • 52 Psychology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences