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Personalized antiplatelet therapy in patients with coronary artery disease undergoing percutaneous coronary intervention: A network meta-analysis of randomized clinical trials.

Publication ,  Journal Article
Kheiri, B; Abdalla, A; Osman, M; Barbarawi, M; Zayed, Y; Haykal, T; Chahine, A; Bachuwa, G; Hassan, M; Bhatt, DL
Published in: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
August 2019

This study aimed to evaluate the efficacy and safety of genotype- and phenotype-guided intensified antiplatelet therapy compared with conventional therapy in patients undergoing stent implantation.Although potent P2Y12 receptor inhibitors are recommended for percutaneous coronary intervention (PCI)-treated acute coronary syndrome, their usage is limited by a high bleeding risk. Therefore, personalized antiplatelet therapy could provide a valuable foundation for selection of antiplatelet therapy in this population.We conducted a Bayesian network meta-analysis for all randomized clinical trials (RCTs) that evaluated genotype- and/or phenotype-guided therapy in PCI-treated coronary artery disease.Thirteen RCTs were included with a total of 6,845 patients. The results showed no significant differences in major adverse cardiovascular events (MACE) between the treatment options ((genotype guided vs. standard of care; OR 0.64; 95% CI: 0.38-1.05) and (phenotype vs. standard of care; OR 0.93; 95% CI: 0.54-1.37)). In addition, no significant differences were demonstrated in bleeding events ((genotype guided vs. standard of care; OR 0.73; 95% CI: 0.45-1.25) and (phenotype vs. standard of care; OR 0.90; 95% CI: 0.62-1.39)).In this mixed treatment meta-analysis of RCTs, neither genotype- nor phenotype-guided antiplatelet therapy in patients with PCI-treated coronary artery disease was superior to conventional therapy.

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Published In

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

DOI

EISSN

1522-726X

ISSN

1522-1946

Publication Date

August 2019

Volume

94

Issue

2

Start / End Page

181 / 186

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Precision Medicine
  • Platelet Aggregation Inhibitors
  • Pharmacogenomic Variants
  • Pharmacogenomic Testing
  • Percutaneous Coronary Intervention
  • Patient Selection
  • Network Meta-Analysis
 

Citation

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MLA
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Kheiri, B., Abdalla, A., Osman, M., Barbarawi, M., Zayed, Y., Haykal, T., … Bhatt, D. L. (2019). Personalized antiplatelet therapy in patients with coronary artery disease undergoing percutaneous coronary intervention: A network meta-analysis of randomized clinical trials. Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions, 94(2), 181–186. https://doi.org/10.1002/ccd.28075
Kheiri, Babikir, Ahmed Abdalla, Mohammed Osman, Mahmoud Barbarawi, Yazan Zayed, Tarek Haykal, Adam Chahine, Ghassan Bachuwa, Mustafa Hassan, and Deepak L. Bhatt. “Personalized antiplatelet therapy in patients with coronary artery disease undergoing percutaneous coronary intervention: A network meta-analysis of randomized clinical trials.Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions 94, no. 2 (August 2019): 181–86. https://doi.org/10.1002/ccd.28075.
Kheiri B, Abdalla A, Osman M, Barbarawi M, Zayed Y, Haykal T, et al. Personalized antiplatelet therapy in patients with coronary artery disease undergoing percutaneous coronary intervention: A network meta-analysis of randomized clinical trials. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2019 Aug;94(2):181–6.
Kheiri, Babikir, et al. “Personalized antiplatelet therapy in patients with coronary artery disease undergoing percutaneous coronary intervention: A network meta-analysis of randomized clinical trials.Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions, vol. 94, no. 2, Aug. 2019, pp. 181–86. Epmc, doi:10.1002/ccd.28075.
Kheiri B, Abdalla A, Osman M, Barbarawi M, Zayed Y, Haykal T, Chahine A, Bachuwa G, Hassan M, Bhatt DL. Personalized antiplatelet therapy in patients with coronary artery disease undergoing percutaneous coronary intervention: A network meta-analysis of randomized clinical trials. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2019 Aug;94(2):181–186.
Journal cover image

Published In

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

DOI

EISSN

1522-726X

ISSN

1522-1946

Publication Date

August 2019

Volume

94

Issue

2

Start / End Page

181 / 186

Related Subject Headings

  • Treatment Outcome
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Precision Medicine
  • Platelet Aggregation Inhibitors
  • Pharmacogenomic Variants
  • Pharmacogenomic Testing
  • Percutaneous Coronary Intervention
  • Patient Selection
  • Network Meta-Analysis