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Dried Blood Spot Biomarkers of Oxidative Stress and Inflammation Associated with Blood Pressure in Rural Senegalese Women with Incident Hypertension.

Publication ,  Journal Article
Lin, Y; Wang, X; Lenz, L; Ndiaye, O; Qin, J; Wang, X; Huang, H; Jeuland, MA; Zhang, J
Published in: Antioxidants (Basel, Switzerland)
December 2021

Blood biomarkers of oxidative stress and inflammation have been associated with increased risk of hypertension development; yet their application in sub-Saharan Africa has been limited due to the lack of blood collection facilities. In this study, we evaluated the usefulness of dried blood spots (DBS), a more feasible alternative to venous blood, in rural sub-Saharan residents. We recruited 342 women with incident hypertension from rural Senegal, and measured C-reactive protein (CRP) and malondialdehyde (MDA) in DBS and concurrent blood pressure (BP) at baseline and 1-year follow-up. Associations of DBS biomarkers with current levels of and 1-year changes in BP were examined after adjusting for demographic, medical, and socioeconomic covariates. DBS concentrations of MDA were significantly associated with concurrent systolic BP (SBP) (p < 0.05), while DBS baseline concentrations of CRP were associated with longitudinal changes in SBP between baseline and follow-up. Compared to participants with baseline CRP < 1 mg/L, those with CRP of 1-3 mg/L and 3-10 mg/L had 2.11 mmHg (95%CI: -2.79 to 7.02 mmHg) and 4.68 mmHg (95%CI: 0.01 to 9.36 mmHg) increases in SBP at follow-up, respectively. The results support the use of DBS biomarkers for hypertension prevention and control, especially in settings with limited clinical resources.

Duke Scholars

Published In

Antioxidants (Basel, Switzerland)

DOI

EISSN

2076-3921

ISSN

2076-3921

Publication Date

December 2021

Volume

10

Issue

12

Start / End Page

2026

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 3205 Medical biochemistry and metabolomics
  • 3101 Biochemistry and cell biology
 

Citation

APA
Chicago
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MLA
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Lin, Y., Wang, X., Lenz, L., Ndiaye, O., Qin, J., Huang, H., … Zhang, J. (2021). Dried Blood Spot Biomarkers of Oxidative Stress and Inflammation Associated with Blood Pressure in Rural Senegalese Women with Incident Hypertension. Antioxidants (Basel, Switzerland), 10(12), 2026. https://doi.org/10.3390/antiox10122026
Lin, Yan, Xiangtian Wang, Luciane Lenz, Ousmane Ndiaye, Jian Qin, Xiaoli Wang, Hui Huang, Marc A. Jeuland, and Junfeng Zhang. “Dried Blood Spot Biomarkers of Oxidative Stress and Inflammation Associated with Blood Pressure in Rural Senegalese Women with Incident Hypertension.Antioxidants (Basel, Switzerland) 10, no. 12 (December 2021): 2026. https://doi.org/10.3390/antiox10122026.
Lin Y, Wang X, Lenz L, Ndiaye O, Qin J, Huang H, et al. Dried Blood Spot Biomarkers of Oxidative Stress and Inflammation Associated with Blood Pressure in Rural Senegalese Women with Incident Hypertension. Antioxidants (Basel, Switzerland). 2021 Dec;10(12):2026.
Lin, Yan, et al. “Dried Blood Spot Biomarkers of Oxidative Stress and Inflammation Associated with Blood Pressure in Rural Senegalese Women with Incident Hypertension.Antioxidants (Basel, Switzerland), vol. 10, no. 12, Dec. 2021, p. 2026. Epmc, doi:10.3390/antiox10122026.
Lin Y, Wang X, Lenz L, Ndiaye O, Qin J, Huang H, Jeuland MA, Zhang J. Dried Blood Spot Biomarkers of Oxidative Stress and Inflammation Associated with Blood Pressure in Rural Senegalese Women with Incident Hypertension. Antioxidants (Basel, Switzerland). 2021 Dec;10(12):2026.

Published In

Antioxidants (Basel, Switzerland)

DOI

EISSN

2076-3921

ISSN

2076-3921

Publication Date

December 2021

Volume

10

Issue

12

Start / End Page

2026

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 3205 Medical biochemistry and metabolomics
  • 3101 Biochemistry and cell biology