Interactions between highly active antiretroviral therapy and over-the-counter agents: a cautionary note.

Journal Article (Journal Article)

Highly active antiretroviral therapy (HAART) has dramatically lowered rates of mother-to-child HIV transmission among patients with access to treatment. Barriers to complete viral suppression increase rates of transmission, even with only low levels of viral replication. Here, we present the case of a pregnant patient who developed a detectable viral load in pregnancy, thought to be related to calcium supplement consumption or emesis while using a dolutegravir-based HAART regimen. Ultimately, with adjustments, the patient again reached an undetectable viral load and had an uncomplicated perinatal and neonatal outcome. We discuss new data on the use of dolutegravir in pregnancy and precautions for maintaining viral suppression while on antiretroviral therapy in pregnancy.

Full Text

Duke Authors

Cited Authors

  • Federspiel, J; Bukhari, MJ; Hamill, MM

Published Date

  • January 6, 2021

Published In

Volume / Issue

  • 14 / 1

PubMed ID

  • 33408101

Pubmed Central ID

  • PMC7789039

Electronic International Standard Serial Number (EISSN)

  • 1757-790X

Digital Object Identifier (DOI)

  • 10.1136/bcr-2020-236655


  • eng

Conference Location

  • England