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Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study.

Publication ,  Journal Article
Akinyemiju, T; Oyekunle, T; Salako, O; Gupta, A; Alatise, O; Ogun, G; Adeniyi, A; Deveaux, A; Hall, A; Ayandipo, O; Olajide, T; Olasehinde, O ...
Published in: Clin Breast Cancer
June 2022

BACKGROUND: Metabolic syndrome (MetS) is characterized by a cluster of biological irregularities. The purpose of this analysis was to examine the association of MetS with BC among Nigerian women, and for the first time evaluate this association by molecular subtype. MATERIALS AND METHODS: MetS was defined as having at least 3 out of 5 of: high blood pressure (≥ 130/85 mm Hg), reduced HDL (< 50 mg/dL), elevated triglyceride (> 150 mg/dL), high waist circumference (≥ 80 cm), and prior diagnosis of diabetes or elevated fasting glucose level (≥ 100 mg/dL). Among 296 newly diagnosed BC cases and 259 healthy controls, multivariable logistic regression models were utilized to estimate adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) for the association between MetS and BC overall. Multinomial logistic regression models were used to evaluate each molecular subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC). RESULTS: After adjusting for age, socio-demographic and reproductive risk factors, there was a positive association between MetS and BC (aOR: 1.84, 95% CI: 1.07, 3.16). In stratified analyses, MetS was associated with BC regardless of BMI status; however, the estimate was significant only among normal weight women (aOR: 3.85; 95% CI: 1.25, 11.90). MetS was significantly associated with TNBC subtype (aOR: 4.37, 95% CI: 1.67, 11.44); associations for other molecular subtypes were not statistically significant. CONCLUSION: MetS appears to be a robust risk factor for BC, particularly for TNBC. Public health and clinical interventions can provide substantial benefits in reducing the burden of MetS and preventing BC among Nigerian women.

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Published In

Clin Breast Cancer

DOI

EISSN

1938-0666

Publication Date

June 2022

Volume

22

Issue

4

Start / End Page

e463 / e472

Location

United States

Related Subject Headings

  • Waist Circumference
  • Triple Negative Breast Neoplasms
  • Risk Factors
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Metabolic Syndrome
  • Humans
  • Female
  • Breast Neoplasms
  • 3211 Oncology and carcinogenesis
 

Citation

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Akinyemiju, T., Oyekunle, T., Salako, O., Gupta, A., Alatise, O., Ogun, G., … Daramola, A. (2022). Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study. Clin Breast Cancer, 22(4), e463–e472. https://doi.org/10.1016/j.clbc.2021.11.004
Akinyemiju, Tomi, Taofik Oyekunle, Omolola Salako, Anjali Gupta, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, et al. “Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study.Clin Breast Cancer 22, no. 4 (June 2022): e463–72. https://doi.org/10.1016/j.clbc.2021.11.004.
Akinyemiju T, Oyekunle T, Salako O, Gupta A, Alatise O, Ogun G, et al. Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study. Clin Breast Cancer. 2022 Jun;22(4):e463–72.
Akinyemiju, Tomi, et al. “Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study.Clin Breast Cancer, vol. 22, no. 4, June 2022, pp. e463–72. Pubmed, doi:10.1016/j.clbc.2021.11.004.
Akinyemiju T, Oyekunle T, Salako O, Gupta A, Alatise O, Ogun G, Adeniyi A, Deveaux A, Hall A, Ayandipo O, Olajide T, Olasehinde O, Arowolo O, Adisa A, Afuwape O, Olusanya A, Adegoke A, Tollefsbol TO, Arnett D, Muehlbauer MJ, Newgard CB, H3 Africa Kidney Research Network, Daramola A. Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study. Clin Breast Cancer. 2022 Jun;22(4):e463–e472.
Journal cover image

Published In

Clin Breast Cancer

DOI

EISSN

1938-0666

Publication Date

June 2022

Volume

22

Issue

4

Start / End Page

e463 / e472

Location

United States

Related Subject Headings

  • Waist Circumference
  • Triple Negative Breast Neoplasms
  • Risk Factors
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Metabolic Syndrome
  • Humans
  • Female
  • Breast Neoplasms
  • 3211 Oncology and carcinogenesis