A family of long reiterated DNA sequences, one copy of which is next to the human beta globin gene.

Journal Article (Journal Article)

An unusually long repeated DNA sequence was identified in cloned DNA, three kb 3' to the human beta-globin gene. Other members of this repeated sequence family were isolated from a human genomic DNA library and characterized by Southern blotting techniques, electron microscopy, and solution hybridization. The copy located next to the beta-globin gene was found to be 6.4 +/- 0.2 kb long and continuous over that length. This repeated sequence family comprises about 1% of the human genome and contains 3000-4800 copies of moderate sequence divergence which are interspersed with other less-highly repeated DNA. The 6.4 kb repeated unit does not appear to be composed of any smaller tandemly repeated subunits, nor is it expressed at a high level in bone marrow cell RNA.

Full Text

Duke Authors

Cited Authors

  • Adams, JW; Kaufman, RE; Kretschmer, PJ; Harrison, M; Nienhuis, AW

Published Date

  • December 20, 1980

Published In

Volume / Issue

  • 8 / 24

Start / End Page

  • 6113 - 6128

PubMed ID

  • 6258162

Pubmed Central ID

  • PMC328076

International Standard Serial Number (ISSN)

  • 0305-1048

Digital Object Identifier (DOI)

  • 10.1093/nar/8.24.6113


  • eng

Conference Location

  • England