Expression of p53 and pRb in bladder and prostate cancers of patients having both cancers.

Journal Article (Journal Article)

Evidence has been presented that tumor suppressor genes p53 and Rb play a crucial role in the development of both human prostate and bladder cancer. Patients with either cancer are at an increased risk for developing the other malignancy as compared to the general population. The purpose of the present study was to investigate whether there is abnormal expression of these two suppressor proteins in both the bladder and prostate cancers of the same patient. The expression of p53 and pRb in bladder and prostate cancer specimens obtained from 15 patients having both cancers was studied using immunohistochemical staining with antibodies against these proteins. The expression of p53 and pRb in both bladder and prostate cancers of the same patient was congruent in 8 of 15 cases (53%) for p53 and 9 of 15 cases (60%) for pRb. The significance of these findings warrants further investigations.

Full Text

Duke Authors

Cited Authors

  • Singh, A; Jones, RF; Friedman, H; Hathir, S; Soos, G; Zabo, A; Haas, GP

Published Date

  • November 1999

Published In

Volume / Issue

  • 19 / 6B

Start / End Page

  • 5415 - 5417

PubMed ID

  • 10697570

International Standard Serial Number (ISSN)

  • 0250-7005

Language

  • eng

Conference Location

  • Greece