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Interaction between plant-based dietary pattern and air pollution on cognitive function: a prospective cohort analysis of Chinese older adults.

Publication ,  Journal Article
Zhu, A; Chen, H; Shen, J; Wang, X; Li, Z; Zhao, A; Shi, X; Yan, L; Zeng, Y; Yuan, C; Ji, JS
Published in: Lancet Reg Health West Pac
March 2022

BACKGROUND: Air pollution is a risk factor for poor cognitive function, while a plant-based dietary pattern is associated with better cognitive function. We aimed to explore their interaction with cognitive function among older adults. METHODS: We used a prospective cohort of old individuals, including 6525 participants of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), aged 65-110 years and with normal cognition at baseline. Air pollution measurement was derived using satellite-derived annual average fine particulate matter (PM2.5) concentrations based on residential locations. Plant-based diet index (PDI) was calculated using survey responses to assess the dietary pattern. Repeated measures of the Mini-Mental State Examination (MMSE) were utilized to assess cognitive function. We applied the Cox proportional hazard regression to explore the associations and further stratified the analysis by PDI. FINDINGS: During a median of 5·6-year follow-up, 1537 (23·6%) out of 6525 participants with normal cognition at baseline developed poor cognitive function (MMSE <18). Living in areas with the highest quintile of cumulative PM2.5 was associated with a 46% increase in the risk of developing poor cognitive function (hazard ratio (HR): 1·46, 95% confidence interval (CI): 1·20, 1·77), compared to those living in areas with the lowest quintile. We observed a significant interaction between cumulative PM2.5 and PDI (p-interaction: 0·04), with the corresponding associations of cumulative PM2.5 being more pronounced among participants with lower PDI (HR: 1·68, 95% CI: 1·26, 2·24) than those with higher PDI (HR: 1·28, 95% CI: 0·98, 1·68). INTERPRETATION: Plant-based dietary pattern may attenuate detrimental impacts of PM2.5 on cognitive function among older adults. Adherence to the plant-based dietary pattern could be used to prevent adverse neurological effects caused by air pollution, especially in developing regions.

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Published In

Lancet Reg Health West Pac

DOI

EISSN

2666-6065

Publication Date

March 2022

Volume

20

Start / End Page

100372

Location

England

Related Subject Headings

  • 4206 Public health
  • 4203 Health services and systems
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhu, A., Chen, H., Shen, J., Wang, X., Li, Z., Zhao, A., … Ji, J. S. (2022). Interaction between plant-based dietary pattern and air pollution on cognitive function: a prospective cohort analysis of Chinese older adults. Lancet Reg Health West Pac, 20, 100372. https://doi.org/10.1016/j.lanwpc.2021.100372
Zhu, Anna, Hui Chen, Jie Shen, Xiaoxi Wang, Zhihui Li, Ai Zhao, Xiaoming Shi, et al. “Interaction between plant-based dietary pattern and air pollution on cognitive function: a prospective cohort analysis of Chinese older adults.Lancet Reg Health West Pac 20 (March 2022): 100372. https://doi.org/10.1016/j.lanwpc.2021.100372.
Zhu A, Chen H, Shen J, Wang X, Li Z, Zhao A, et al. Interaction between plant-based dietary pattern and air pollution on cognitive function: a prospective cohort analysis of Chinese older adults. Lancet Reg Health West Pac. 2022 Mar;20:100372.
Zhu, Anna, et al. “Interaction between plant-based dietary pattern and air pollution on cognitive function: a prospective cohort analysis of Chinese older adults.Lancet Reg Health West Pac, vol. 20, Mar. 2022, p. 100372. Pubmed, doi:10.1016/j.lanwpc.2021.100372.
Zhu A, Chen H, Shen J, Wang X, Li Z, Zhao A, Shi X, Yan L, Zeng Y, Yuan C, Ji JS. Interaction between plant-based dietary pattern and air pollution on cognitive function: a prospective cohort analysis of Chinese older adults. Lancet Reg Health West Pac. 2022 Mar;20:100372.

Published In

Lancet Reg Health West Pac

DOI

EISSN

2666-6065

Publication Date

March 2022

Volume

20

Start / End Page

100372

Location

England

Related Subject Headings

  • 4206 Public health
  • 4203 Health services and systems
  • 3202 Clinical sciences