Potential role of granulocyte-monocyte colony-stimulating factor in the progression of intracranial aneurysms.

Journal Article (Journal Article)

Macrophages play a central role in the inflammatory response leading to aneurysm formation, progression, and rupture. The purpose of this study was to determine whether granulocyte-monocyte colony-stimulating factor (GM-CSF) plays a role in the progression of human intracranial aneurysms. Specifically, we investigated whether there was a correlation between the aneurysm size and the concentration of GM-CSF in the lumen of intracranial aneurysms. The concentrations of GM-CSF in blood samples drawn from the lumen of 15 human unruptured saccular intracranial aneurysms of 14 consecutive patients were compared. The aneurysm size was 10.3±9 mm on average. The mean plasma concentration of GM-CSF was 27.9±3.1 pg/mL in the lumen of intracranial aneurysms. The mean plasma concentration of GM-CSF was significantly higher in aneurysms larger than 7 mm (30.1±2.8 pg/mL) compared with aneurysms smaller than 7 mm (26.4±2.4 pg/mL; p=0.02). There was a significant positive correlation between the aneurysm size and the plasma concentration of GM-CSF (Spearman's rho=0.55; p=0.04). There is a significant positive correlation between the aneurysm size and the plasma concentration of GM-CSF in aneurysm lumens. This suggests that GM-CSF, through its stimulatory function on macrophages, may promote aneurysm progression and may be a possible therapeutic target.

Full Text

Duke Authors

Cited Authors

  • Chalouhi, N; Theofanis, T; Starke, RM; Zanaty, M; Jabbour, P; Dooley, SA; Hasan, D

Published Date

  • January 2015

Published In

Volume / Issue

  • 34 / 1

Start / End Page

  • 78 - 81

PubMed ID

  • 25389911

Pubmed Central ID

  • PMC4281873

Electronic International Standard Serial Number (EISSN)

  • 1557-7430

Digital Object Identifier (DOI)

  • 10.1089/dna.2014.2618

Language

  • eng

Conference Location

  • United States