Vascular smooth muscle cells in cerebral aneurysm pathogenesis.

Journal Article (Journal Article;Review)

Vascular smooth muscle cells (SMC) maintain significant plasticity. Following environmental stimulation, SMC can alter their phenotype from one primarily concerned with contraction to a pro-inflammatory and matrix remodeling phenotype. This is a critical process behind peripheral vascular disease and atherosclerosis, a key element of cerebral aneurysm pathology. Evolving evidence demonstrates that SMCs and phenotypic modulation play a significant role in cerebral aneurysm formation and rupture. Pharmacological alteration of smooth muscle cell function and phenotypic modulation could provide a promising medical therapy to inhibit cerebral aneurysm progression. This study reviews vascular SMC function and its contribution to cerebral aneurysm pathophysiology.

Full Text

Duke Authors

Cited Authors

  • Starke, RM; Chalouhi, N; Ding, D; Raper, DMS; Mckisic, MS; Owens, GK; Hasan, DM; Medel, R; Dumont, AS

Published Date

  • June 2014

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 338 - 346

PubMed ID

  • 24323713

Electronic International Standard Serial Number (EISSN)

  • 1868-601X

Digital Object Identifier (DOI)

  • 10.1007/s12975-013-0290-1


  • eng

Conference Location

  • United States