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Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation.

Publication ,  Journal Article
Hasan, DM; Amans, M; Tihan, T; Hess, C; Guo, Y; Cha, S; Su, H; Martin, AJ; Lawton, MT; Neuwelt, EA; Saloner, DA; Young, WL
Published in: Transl Stroke Res
July 2012

Inflammation cell infiltration and cytokine expression are seen in the vascular walls and intervening stroma of resected brain arteriovenous malformation (bAVM) specimens, even in unruptured and previously untreated lesions. Macrophages may play a critical role in bAVM progression to rupture, and could serve as a marker for rupture risk. We assessed feasibility of imaging macrophages within the bAVM nidus using ferumoxytol-enhanced MRI in four patients with already diagnosed bAVMs using iron-sensitive imaging (ISI; T2*-GE-MRI sequence). Patients were imaged at baseline and at either 1 day (n=2) or 5 days (n=2) after infusion of 5mg/kg of ferumoxytol. Residual intravascular ferumoxytol obscured evaluation for uptake in bAVM vascular walls and stroma at the 1-day time point. The two cases imaged at 5 days showed less intravascular tracer but had signal loss in the nidal region consistent with ferumoxytol localization. One case underwent surgical resection; there was prominent vascular wall CD68 staining. Ferumoxytol-enhanced-MRI for assessing bAVM inflammatory cell burden appears feasible and has the potential to be developed as a biomarker to study lesional inflammatory events.

Duke Scholars

Published In

Transl Stroke Res

DOI

EISSN

1868-601X

Publication Date

July 2012

Volume

3

Issue

Suppl 1

Start / End Page

166 / 173

Location

United States

Related Subject Headings

  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hasan, D. M., Amans, M., Tihan, T., Hess, C., Guo, Y., Cha, S., … Young, W. L. (2012). Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation. Transl Stroke Res, 3(Suppl 1), 166–173. https://doi.org/10.1007/s12975-012-0172-y
Hasan, David M., Matthew Amans, Tarik Tihan, Christopher Hess, Yi Guo, Soonmee Cha, Hua Su, et al. “Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation.Transl Stroke Res 3, no. Suppl 1 (July 2012): 166–73. https://doi.org/10.1007/s12975-012-0172-y.
Hasan DM, Amans M, Tihan T, Hess C, Guo Y, Cha S, et al. Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation. Transl Stroke Res. 2012 Jul;3(Suppl 1):166–73.
Hasan, David M., et al. “Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation.Transl Stroke Res, vol. 3, no. Suppl 1, July 2012, pp. 166–73. Pubmed, doi:10.1007/s12975-012-0172-y.
Hasan DM, Amans M, Tihan T, Hess C, Guo Y, Cha S, Su H, Martin AJ, Lawton MT, Neuwelt EA, Saloner DA, Young WL. Ferumoxytol-enhanced MRI to Image Inflammation within Human Brain Arteriovenous Malformations: A Pilot Investigation. Transl Stroke Res. 2012 Jul;3(Suppl 1):166–173.
Journal cover image

Published In

Transl Stroke Res

DOI

EISSN

1868-601X

Publication Date

July 2012

Volume

3

Issue

Suppl 1

Start / End Page

166 / 173

Location

United States

Related Subject Headings

  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1109 Neurosciences
  • 1103 Clinical Sciences