Molecular imaging of cerebrovascular lesions.

Journal Article (Journal Article;Review)

Inflammation is a key component in the pathogenesis of cerebrovascular lesions. Two agents have emerged as promising possibilities for imaging cerebrovascular lesions. These agents are ferumoxytol and myeloperoxidase (MPO)-specific paramagnetic magnetic resonance (MR) contrast agent. Ferumoxytol is an iron oxide nanoparticle coated by a carbohydrate shell that is used in MRI studies as an inflammatory marker as it is cleared by macrophages. Ferumoxytol-enhanced MRI allows noninvasive assessment of the inflammatory status of cerebral aneurysms and arteriovenous malformations and, possibly, may differentiate "unstable" lesions that require early intervention from "stable" lesions that can be safely observed. Several pilot studies have also suggested that MPO-specific paramagnetic MR contrast agent, di-5-hydroxytryptamide of gadopentetate dimeglumine, may allow imaging of inflammation in the wall of saccular aneurysms in animal models. However, studies in human subjects have yet to be performed. In this paper, we review current data regarding ferumoxytol-enhanced MRI and MPO-specific paramagnetic MR contrast agent and discuss current and future applications.

Full Text

Duke Authors

Cited Authors

  • Chalouhi, N; Jabbour, P; Magnotta, V; Hasan, D

Published Date

  • April 2014

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • 260 - 268

PubMed ID

  • 24323714

Electronic International Standard Serial Number (EISSN)

  • 1868-601X

Digital Object Identifier (DOI)

  • 10.1007/s12975-013-0291-0

Language

  • eng

Conference Location

  • United States