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Global Sensitivity Analysis For Clinically Validated 1D Models of Fractional Flow Reserve.

Publication ,  Journal Article
Tanade, C; Feiger, B; Vardhan, M; Chen, SJ; Leopold, JA; Randles, A
Published in: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
November 2021

Computation of Fractional Flow Reserve (FFR) through computational fluid dynamics (CFD) is used to guide intervention and often uses a number of clinically-derived metrics, but these patient-specific data could be costly and difficult to obtain. Understanding which parameters can be approximated from population averages and which parameters need to be patient-specific is important and remains largely unexplored. In this study, we performed a global sensitivity study on two 1D models of FFR to identify the most influential patient parameters. Our results indicated that vessel compliance, cardiac cycle period, flow rate, density, viscosity, and elastic modulus contributed minimally to the variance in FFR and may be approximated from population averages. On the other hand, outlet resistance (i.e., microvascular resistance), stenosis degree, and percent stenosis length contributed the most to FFR computation and needed to be tuned to the patient of interest. Selective measuring of patient-specific parameters may significantly reduce costs and streamline the simulation pipeline without reducing accuracy.

Duke Scholars

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

DOI

EISSN

2694-0604

ISSN

2375-7477

Publication Date

November 2021

Volume

2021

Start / End Page

4395 / 4398

Related Subject Headings

  • Predictive Value of Tests
  • Hydrodynamics
  • Humans
  • Fractional Flow Reserve, Myocardial
  • Coronary Stenosis
  • Coronary Angiography
 

Citation

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Tanade, C., Feiger, B., Vardhan, M., Chen, S. J., Leopold, J. A., & Randles, A. (2021). Global Sensitivity Analysis For Clinically Validated 1D Models of Fractional Flow Reserve. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2021, 4395–4398. https://doi.org/10.1109/embc46164.2021.9629890
Tanade, Cyrus, Bradley Feiger, Madhurima Vardhan, S James Chen, Jane A. Leopold, and Amanda Randles. “Global Sensitivity Analysis For Clinically Validated 1D Models of Fractional Flow Reserve.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2021 (November 2021): 4395–98. https://doi.org/10.1109/embc46164.2021.9629890.
Tanade C, Feiger B, Vardhan M, Chen SJ, Leopold JA, Randles A. Global Sensitivity Analysis For Clinically Validated 1D Models of Fractional Flow Reserve. Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual International Conference. 2021 Nov;2021:4395–8.
Tanade, Cyrus, et al. “Global Sensitivity Analysis For Clinically Validated 1D Models of Fractional Flow Reserve.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, vol. 2021, Nov. 2021, pp. 4395–98. Epmc, doi:10.1109/embc46164.2021.9629890.
Tanade C, Feiger B, Vardhan M, Chen SJ, Leopold JA, Randles A. Global Sensitivity Analysis For Clinically Validated 1D Models of Fractional Flow Reserve. Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual International Conference. 2021 Nov;2021:4395–4398.

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

DOI

EISSN

2694-0604

ISSN

2375-7477

Publication Date

November 2021

Volume

2021

Start / End Page

4395 / 4398

Related Subject Headings

  • Predictive Value of Tests
  • Hydrodynamics
  • Humans
  • Fractional Flow Reserve, Myocardial
  • Coronary Stenosis
  • Coronary Angiography