Microenvironmental influences on T cell immunity in cancer and inflammation.

Journal Article (Journal Article;Review)

T cell metabolism is dynamic and highly regulated. While the intrinsic metabolic programs of T cell subsets are integral to their distinct differentiation and functional patterns, the ability of cells to acquire nutrients and cope with hostile microenvironments can limit these pathways. T cells must function in a wide variety of tissue settings, and how T cells interpret these signals to maintain an appropriate metabolic program for their demands or if metabolic mechanisms of immune suppression restrain immunity is an area of growing importance. Both in inflamed and cancer tissues, a wide range of changes in physical conditions and nutrient availability are now acknowledged to shape immunity. These include fever and increased temperatures, depletion of critical micro and macro-nutrients, and accumulation of inhibitory waste products. Here we review several of these factors and how the tissue microenvironment both shapes and constrains immunity.

Full Text

Duke Authors

Cited Authors

  • Heintzman, DR; Fisher, EL; Rathmell, JC

Published Date

  • March 2022

Published In

Volume / Issue

  • 19 / 3

Start / End Page

  • 316 - 326

PubMed ID

  • 35039633

Pubmed Central ID

  • PMC8762638

Electronic International Standard Serial Number (EISSN)

  • 2042-0226

Digital Object Identifier (DOI)

  • 10.1038/s41423-021-00833-2


  • eng

Conference Location

  • China