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Reproductive Factors Do Not Influence Survival with Ovarian Cancer.

Publication ,  Journal Article
Phung, MT; Alimujiang, A; Berchuck, A; Anton-Culver, H; Schildkraut, JM; Bandera, EV; Chang-Claude, J; Chase, A; Doherty, JA; Grout, B; Lee, AW ...
Published in: Cancer Epidemiol Biomarkers Prev
April 1, 2022

BACKGROUND: Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes. METHODS: Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian tube, or primary peritoneal cancer (ovarian cancer) from 16 studies in the Ovarian Cancer Association Consortium (OCAC), we examined the associations between survival and age at menarche, combined oral contraceptive use, parity, breastfeeding, age at last pregnancy, and menopausal status using Cox proportional hazard models. The models were adjusted for age at diagnosis, race/ethnicity, education level, and OCAC study and stratified on stage and histotype. RESULTS: During the mean follow-up of 6.34 years (SD = 4.80), 6,418 patients passed away (57.4%). There was no evidence of associations between the reproductive factors and survival among patients with ovarian cancer overall or by histotype. CONCLUSIONS: This study found no association between reproductive factors and survival after an ovarian cancer diagnosis. IMPACT: Reproductive factors are well-established risk factors for ovarian cancer, but they are not associated with survival after a diagnosis of ovarian cancer.

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

April 1, 2022

Volume

31

Issue

4

Start / End Page

909 / 913

Location

United States

Related Subject Headings

  • Risk Factors
  • Reproductive History
  • Pregnancy
  • Parity
  • Ovarian Neoplasms
  • Menarche
  • Humans
  • Female
  • Epidemiology
  • Carcinoma, Ovarian Epithelial
 

Citation

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Phung, M. T., Alimujiang, A., Berchuck, A., Anton-Culver, H., Schildkraut, J. M., Bandera, E. V., … Pearce, C. L. (2022). Reproductive Factors Do Not Influence Survival with Ovarian Cancer. Cancer Epidemiol Biomarkers Prev, 31(4), 909–913. https://doi.org/10.1158/1055-9965.EPI-21-1091
Phung, Minh Tung, Aliya Alimujiang, Andrew Berchuck, Hoda Anton-Culver, Joellen M. Schildkraut, Elisa V. Bandera, Jenny Chang-Claude, et al. “Reproductive Factors Do Not Influence Survival with Ovarian Cancer.Cancer Epidemiol Biomarkers Prev 31, no. 4 (April 1, 2022): 909–13. https://doi.org/10.1158/1055-9965.EPI-21-1091.
Phung MT, Alimujiang A, Berchuck A, Anton-Culver H, Schildkraut JM, Bandera EV, et al. Reproductive Factors Do Not Influence Survival with Ovarian Cancer. Cancer Epidemiol Biomarkers Prev. 2022 Apr 1;31(4):909–13.
Phung, Minh Tung, et al. “Reproductive Factors Do Not Influence Survival with Ovarian Cancer.Cancer Epidemiol Biomarkers Prev, vol. 31, no. 4, Apr. 2022, pp. 909–13. Pubmed, doi:10.1158/1055-9965.EPI-21-1091.
Phung MT, Alimujiang A, Berchuck A, Anton-Culver H, Schildkraut JM, Bandera EV, Chang-Claude J, Chase A, Doherty JA, Grout B, Goodman MT, Hanley GE, Lee AW, McKinnon Deurloo C, Menon U, Modugno F, Pharoah PDP, Pike MC, Richardson J, Risch HA, Sieh W, Terry KL, Webb PM, Wentzensen N, Wu AH, Pearce CL. Reproductive Factors Do Not Influence Survival with Ovarian Cancer. Cancer Epidemiol Biomarkers Prev. 2022 Apr 1;31(4):909–913.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

April 1, 2022

Volume

31

Issue

4

Start / End Page

909 / 913

Location

United States

Related Subject Headings

  • Risk Factors
  • Reproductive History
  • Pregnancy
  • Parity
  • Ovarian Neoplasms
  • Menarche
  • Humans
  • Female
  • Epidemiology
  • Carcinoma, Ovarian Epithelial