Pitfalls and Successes in Trials in Older Transplant Patients with Hematologic Malignancies.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: Recent medical advances have allowed a greater number of older patients to undergo hematopoietic stem cell transplantation (HSCT) and participate in HSCT trials. In this review, we outline recent advances in HSCT that have made this possible, general setbacks, and their effects on the landscape of HSCT trials in older adults. RECENT FINDINGS: Reduced-intensity conditioning regimens and a more physiological approach to transplant candidate selection have given older patients an opportunity to participate in HSCT trials. However, difficulties in allogeneic donor selection, post-transplant complications, and the misalignment of trial goals with patient goals may pose challenges for future trial recruitment and success. While increasing amounts of evidence show that older adults may benefit from participation in HSCT trials, clinicians, investigators, and patients must carefully weigh the benefits with potential repercussions.

Full Text

Duke Authors

Cited Authors

  • Zhao, AT; Sung, AD

Published Date

  • January 2022

Published In

Volume / Issue

  • 24 / 1

Start / End Page

  • 125 - 133

PubMed ID

  • 35061190

Electronic International Standard Serial Number (EISSN)

  • 1534-6269

Digital Object Identifier (DOI)

  • 10.1007/s11912-022-01194-3


  • eng

Conference Location

  • United States