A dried blood spot method to evaluate cholinesterase activity in young children.

Journal Article (Journal Article)

Field methods are needed to detect and monitor the organophosphate pesticide exposure of young children. Twenty children, aged 11 to 18 mo, living in an agricultural community along the United States/Mexico border were enrolled in a pilot study investigating methods to detect pesticide exposure. Healthy children were recruited at pediatric clinics with the informed consent of their parents. Venous blood samples were collected from children twice, 4 wk apart. Cholinesterase activity was compared in whole heparinized venous blood with venous blood samples dried on filter paper. Although the amount of activity in the dried blood was consistently less than in the heparinized blood, the activity was significantly correlated: Spearman r = .6 (p = 0.01). This dried blood method may be used during field studies to evaluate changes in cholinesterase values in children over time.

Full Text

Duke Authors

Cited Authors

  • Hilborn, ED; Padilla, S

Published Date

  • September 2004

Published In

Volume / Issue

  • 59 / 9

Start / End Page

  • 467 - 470

PubMed ID

  • 16381488

Electronic International Standard Serial Number (EISSN)

  • 2331-4303

International Standard Serial Number (ISSN)

  • 0003-9896

Digital Object Identifier (DOI)

  • 10.1080/00039890409603427


  • eng