Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurotoxicity.

Journal Article (Journal Article)

Deltamethrin (DLM) is a relatively potent and widely used pyrethroid insecticide. Inefficient detoxification has been proposed to be the primary reason for the greater sensitivity of immature rats to the acute neurotoxicity of DLM. The objective of this study was to test this hypothesis by characterizing the age dependence of DLM metabolism in vitro, as well as toxic signs and blood levels of the neurotoxic parent compound following administration of 10 mg DLM/kg p.o. in glycerol formal. Metabolism was quantified in vitro by monitoring the disappearance of the parent compound from plasma [via carboxylesterases (CaEs)] and liver microsomes [via CaEs and cytochromes P450 (P450s)] obtained from 10-, 21-, and 40-day-old male Sprague-Dawley rats. Mean (+/-S.E.) intrinsic clearances (Vmax/Km) in these respective age groups by liver P450s (4.99+/-0.32, 16.99+/-1.85, and 38.45+/-7.03) and by liver CaEs (0.34+/-0.05, 1.77+/-0.38, and 2.53+/-0.19) and plasma CaEs (0.39+/-0.06, 0.80+/-0.09, and 2.28+/-0.56) increased significantly (p

Full Text

Duke Authors

Cited Authors

  • Anand, SS; Kim, K-B; Padilla, S; Muralidhara, S; Kim, HJ; Fisher, JW; Bruckner, JV

Published Date

  • March 2006

Published In

Volume / Issue

  • 34 / 3

Start / End Page

  • 389 - 397

PubMed ID

  • 16326812

Electronic International Standard Serial Number (EISSN)

  • 1521-009X

International Standard Serial Number (ISSN)

  • 0090-9556

Digital Object Identifier (DOI)

  • 10.1124/dmd.105.007807


  • eng