Effects of hypothermia on the in vivo measurement of rapid axonal transport in the rat: a cautionary note.

Journal Article (Journal Article)

Rapid axonal transport of glycoproteins was examined in the retinofugal projections of hypothermic and normothermic adult male Long-Evans hooded rats previously receiving intraocular injections of [3H]fucose. The amount of retinal fucosylation appeared normal in the hypothermic animals 3.5 h after isotope injection, but glycoprotein transport was reduced relative to normothermic controls. This reduction was especially pronounced in the most distal structure of the retinofugal tract (superior colliculus). We conclude that rapid axonal transport decreases with reductions in mammalian body temperature. This finding emphasizes the importance of controlling body temperature in in vivo studies of mammalian axonal transport.

Full Text

Duke Authors

Cited Authors

  • Padilla, S; Lyerly, D

Published Date

  • April 1986

Published In

Volume / Issue

  • 46 / 4

Start / End Page

  • 1227 - 1230

PubMed ID

  • 2419507

Electronic International Standard Serial Number (EISSN)

  • 1471-4159

International Standard Serial Number (ISSN)

  • 0022-3042

Digital Object Identifier (DOI)

  • 10.1111/j.1471-4159.1986.tb00642.x


  • eng