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4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice.

Publication ,  Journal Article
Yue, L; Talukder, MAH; Gurjar, A; Lee, JI; Noble, M; Dirksen, RT; Chakkalakal, J; Elfar, JC
Published in: Muscle Nerve
August 2019

INTRODUCTION: We recently demonstrated the beneficial effects of 4-aminopyridine (4-AP), a potassium channel blocker, in enhancing remyelination and recovery of nerve conduction velocity and motor function after sciatic nerve crush injury in mice. Although muscle atrophy occurs very rapidly after nerve injury, the effect of 4-AP on muscle atrophy and intrinsic muscle contractile function is largely unknown. METHODS: Mice were assigned to sciatic nerve crush injury and no-injury groups and were followed for 3, 7, and 14 days with/without 4-AP or saline treatment. Morphological, functional, and transcriptional properties of skeletal muscle were assessed. RESULTS: In addition to improving in vivo function, 4-AP significantly reduced muscle atrophy with increased muscle fiber diameter and contractile force. Reduced muscle atrophy was associated with attenuated expression of atrophy-related genes and increased expression of proliferating stem cells. DISCUSSION: These findings provide new insights into the potential therapeutic benefits of 4-AP against nerve injury-induced muscle atrophy and dysfunction. Muscle Nerve 60: 192-201, 2019.

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Published In

Muscle Nerve

DOI

EISSN

1097-4598

Publication Date

August 2019

Volume

60

Issue

2

Start / End Page

192 / 201

Location

United States

Related Subject Headings

  • Ubiquitin-Protein Ligases
  • Tripartite Motif Proteins
  • Sciatic Nerve
  • Remyelination
  • Regeneration
  • Potassium Channel Blockers
  • Peripheral Nerve Injuries
  • Neurology & Neurosurgery
  • Muscular Atrophy
  • Muscle, Skeletal
 

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Yue, L., Talukder, M. A. H., Gurjar, A., Lee, J. I., Noble, M., Dirksen, R. T., … Elfar, J. C. (2019). 4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice. Muscle Nerve, 60(2), 192–201. https://doi.org/10.1002/mus.26516
Yue, Li, MA Hassan Talukder, Anagha Gurjar, Jung Il Lee, Mark Noble, Robert T. Dirksen, Joe Chakkalakal, and John C. Elfar. “4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice.Muscle Nerve 60, no. 2 (August 2019): 192–201. https://doi.org/10.1002/mus.26516.
Yue L, Talukder MAH, Gurjar A, Lee JI, Noble M, Dirksen RT, et al. 4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice. Muscle Nerve. 2019 Aug;60(2):192–201.
Yue, Li, et al. “4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice.Muscle Nerve, vol. 60, no. 2, Aug. 2019, pp. 192–201. Pubmed, doi:10.1002/mus.26516.
Yue L, Talukder MAH, Gurjar A, Lee JI, Noble M, Dirksen RT, Chakkalakal J, Elfar JC. 4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice. Muscle Nerve. 2019 Aug;60(2):192–201.
Journal cover image

Published In

Muscle Nerve

DOI

EISSN

1097-4598

Publication Date

August 2019

Volume

60

Issue

2

Start / End Page

192 / 201

Location

United States

Related Subject Headings

  • Ubiquitin-Protein Ligases
  • Tripartite Motif Proteins
  • Sciatic Nerve
  • Remyelination
  • Regeneration
  • Potassium Channel Blockers
  • Peripheral Nerve Injuries
  • Neurology & Neurosurgery
  • Muscular Atrophy
  • Muscle, Skeletal