Insights into muscle stem cell dynamics during postnatal development.

Journal Article (Journal Article;Review)

During development, resident stem cell populations contribute to the growth and maturation of tissue and organs. In skeletal muscle, muscle stem cells, or satellite cells (SCs), are responsible for the maturation of postnatal myofibers. However, the role SCs play in later stages of postnatal growth, and thus, when they enter a mature quiescent state is controversial. Here, we discuss the current literature regarding the role SCs play in all stages of postnatal growth, from birth to puberty onset to young adulthood. We additionally highlight the implications of SC loss or dysfunction during developmental stages, both in the context of experimental paradigms and disease settings.

Full Text

Duke Authors

Cited Authors

  • Bachman, JF; Chakkalakal, JV

Published Date

  • May 2022

Published In

Volume / Issue

  • 289 / 10

Start / End Page

  • 2710 - 2722

PubMed ID

  • 33811430

Electronic International Standard Serial Number (EISSN)

  • 1742-4658

Digital Object Identifier (DOI)

  • 10.1111/febs.15856


  • eng

Conference Location

  • England