Cryptococcus at work: gene expression during human infection.

Journal Article (Journal Article)

Meningitis is a frequent manifestation of infection due to Cryptococcus neoformans and a major cause of increased morbidity in patients with AIDS. Numerous in vitro gene expression and genetic studies of the fungus have predicted a myriad of genes, pathways, and biological processes that may be critical for pathogenesis, and many studies using animal models have supported the role of these processes during infection. However, the relevance of these hypotheses based on in vitro and animal models has often been questioned. A recent study by Chen et al. [Y. Chen, D. L. Toffaletti, J. L. Tenor, A. P. Litvintseva, C. Fang, T. G. Mitchell, T. R. McDonald, K. Nielsen, D. R. Boulware, T. Bicanic, and J. R. Perfect, mBio 5(1):e01087-13, 2014] represents an important step in understanding the cryptococcal response during human infection.

Full Text

Duke Authors

Cited Authors

  • Upadhya, R; Donlin, MJ; Lodge, JK

Published Date

  • April 22, 2014

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • e01097 -

PubMed ID

  • 24757217

Pubmed Central ID

  • PMC3994517

Electronic International Standard Serial Number (EISSN)

  • 2150-7511

Digital Object Identifier (DOI)

  • 10.1128/mBio.01097-14

Language

  • eng

Conference Location

  • United States