Thioredoxin reductase is essential for viability in the fungal pathogen Cryptococcus neoformans.

Journal Article (Journal Article)

Thioredoxin reductase (TRR1) is an important component of the thioredoxin oxidative stress resistance pathway. Here we show that it is induced during oxidative and nitrosative stress and is preferentially localized to the mitochondria in Cryptococcus neoformans. The C. neoformans TRR1 gene encodes the low-molecular-weight isoform of the thioredoxin reductase enzyme, which shares little homology with that of its mammalian host. By replacing the endogenous TRR1 promoter with an inducible copper transporter promoter, we showed that Trr1 appears to be essential for viability of this pathogenic fungus, making it a potential antifungal target.

Full Text

Duke Authors

Cited Authors

  • Missall, TA; Lodge, JK

Published Date

  • February 2005

Published In

Volume / Issue

  • 4 / 2

Start / End Page

  • 487 - 489

PubMed ID

  • 15701811

Pubmed Central ID

  • PMC549343

International Standard Serial Number (ISSN)

  • 1535-9778

Digital Object Identifier (DOI)

  • 10.1128/EC.4.2.487-489.2005

Language

  • eng

Conference Location

  • United States