Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans.

Journal Article (Journal Article)

Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosan-deficient syndrome that includes slow growth and decreased cell integrity. Here we demonstrate chitosan is necessary for virulence and persistence in the mammalian host.

Full Text

Duke Authors

Cited Authors

  • Baker, LG; Specht, CA; Lodge, JK

Published Date

  • September 2011

Published In

Volume / Issue

  • 10 / 9

Start / End Page

  • 1264 - 1268

PubMed ID

  • 21784998

Pubmed Central ID

  • PMC3187048

Electronic International Standard Serial Number (EISSN)

  • 1535-9786

Digital Object Identifier (DOI)

  • 10.1128/EC.05138-11


  • eng

Conference Location

  • United States