Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.

Journal Article (Journal Article;Review)

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

Full Text

Duke Authors

Cited Authors

  • McDowell, CM; Kizhatil, K; Elliott, MH; Overby, DR; van Batenburg-Sherwood, J; Millar, JC; Kuehn, MH; Zode, G; Acott, TS; Anderson, MG; Bhattacharya, SK; Bertrand, JA; Borras, T; Bovenkamp, DE; Cheng, L; Danias, J; De Ieso, ML; Du, Y; Faralli, JA; Fuchshofer, R; Ganapathy, PS; Gong, H; Herberg, S; Hernandez, H; Humphries, P; John, SWM; Kaufman, PL; Keller, KE; Kelley, MJ; Kelly, RA; Krizaj, D; Kumar, A; Leonard, BC; Lieberman, RL; Liton, P; Liu, Y; Liu, KC; Lopez, NN; Mao, W; Mavlyutov, T; McDonnell, F; McLellan, GJ; Mzyk, P; Nartey, A; Pasquale, LR; Patel, GC; Pattabiraman, PP; Peters, DM; Raghunathan, V; Rao, PV; Rayana, N; Raychaudhuri, U; Reina-Torres, E; Ren, R; Rhee, D; Chowdhury, UR; Samples, JR; Samples, EG; Sharif, N; Schuman, JS; Sheffield, VC; Stevenson, CH; Soundararajan, A; Subramanian, P; Sugali, CK; Sun, Y; Toris, CB; Torrejon, KY; Vahabikashi, A; Vranka, JA; Wang, T; Willoughby, CE; Xin, C; Yun, H; Zhang, HF; Fautsch, MP; Tamm, ER; Clark, AF; Ethier, CR; Stamer, WD

Published Date

  • February 1, 2022

Published In

Volume / Issue

  • 63 / 2

Start / End Page

  • 12 -

PubMed ID

  • 35129590

Pubmed Central ID

  • PMC8842499

Electronic International Standard Serial Number (EISSN)

  • 1552-5783

Digital Object Identifier (DOI)

  • 10.1167/iovs.63.2.12


  • eng

Conference Location

  • United States