Feedforward mechanisms of cross-orientation interactions in mouse V1.

Journal Article (Journal Article)

Sensory neurons are modulated by context. For example, in mouse primary visual cortex (V1), neuronal responses to the preferred orientation are modulated by the presence of superimposed orientations ("plaids"). The effects of this modulation are diverse; some neurons are suppressed, while others have larger responses to a plaid than its components. We investigated whether this diversity could be explained by a unified circuit mechanism. We report that this masking is maintained during suppression of cortical activity, arguing against cortical mechanisms. Instead, the heterogeneity of plaid responses is explained by an interaction between stimulus geometry and orientation tuning. Highly selective neurons are uniformly suppressed by plaids, whereas the effects in weakly selective neurons depend on the spatial configuration of the stimulus, transitioning systematically between suppression and facilitation. Thus, the diverse responses emerge as a consequence of the spatial structure of feedforward inputs, with no need to invoke cortical interactions.

Full Text

Duke Authors

Cited Authors

  • Barbera, D; Priebe, NJ; Glickfeld, LL

Published Date

  • January 19, 2022

Published In

Volume / Issue

  • 110 / 2

Start / End Page

  • 297 - 311.e4

PubMed ID

  • 34735779

Pubmed Central ID

  • PMC8920535

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2021.10.017

Language

  • eng

Conference Location

  • United States