Traumatic brain injury and dementia risk in male veteran older twins-Controlling for genetic and early life non-genetic factors.

Journal Article (Journal Article)

INTRODUCTION: This study leveraged the twin study design, which controls for shared genetic and early life exposures, to investigate the association between traumatic brain injury (TBI) and dementia. METHODS: Members of the National Academy of Sciences-National Research Council's Twins Registry of World War II male veterans were assigned a cognitive outcome based on a multi-step assessment protocol. History of TBI was obtained via interviews. RESULTS: Among 8302 individuals, risk of non-Alzheimer's disease (non-AD) dementia was higher in those with TBI (hazard ratio [HR] = 2.00, 95% confidence interval [CI], 0.97-4.12), than for AD (HR = 1.23, 95% CI, 0.76-2.00). To add more control of genetic and shared environmental factors, we analyzed 100 twin pairs discordant for both TBI and dementia onset, and found TBI-associated risk for non-AD dementia increased further (McNemar odds ratio = 2.70; 95% CI, 1.27-6.25). DISCUSSION: These findings suggest that non-AD mechanisms may underlie the association between TBI and dementia, potentially providing insight into inconsistent results from prior studies.

Full Text

Duke Authors

Cited Authors

  • Plassman, BL; Chanti-Ketterl, M; Pieper, CF; Yaffe, K

Published Date

  • November 2022

Published In

Volume / Issue

  • 18 / 11

Start / End Page

  • 2234 - 2242

PubMed ID

  • 35102695

Pubmed Central ID

  • PMC9339591

Electronic International Standard Serial Number (EISSN)

  • 1552-5279

Digital Object Identifier (DOI)

  • 10.1002/alz.12571


  • eng

Conference Location

  • United States