Chemotropism and Cell-Cell Fusion in Fungi.

Journal Article (Journal Article;Review)

Fungi exhibit an enormous variety of morphologies, including yeast colonies, hyphal mycelia, and elaborate fruiting bodies. This diversity arises through a combination of polar growth, cell division, and cell fusion. Because fungal cells are nonmotile and surrounded by a protective cell wall that is essential for cell integrity, potential fusion partners must grow toward each other until they touch and then degrade the intervening cell walls without impacting cell integrity. Here, we review recent progress on understanding how fungi overcome these challenges. Extracellular chemoattractants, including small peptide pheromones, mediate communication between potential fusion partners, promoting the local activation of core cell polarity regulators to orient polar growth and cell wall degradation. However, in crowded environments, pheromone gradients can be complex and potentially confusing, raising the question of how cells can effectively find their partners. Recent findings suggest that the cell polarity circuit exhibits searching behavior that can respond to pheromone cues through a remarkably flexible and effective strategy called exploratory polarization.

Full Text

Duke Authors

Cited Authors

  • Clark-Cotton, MR; Jacobs, KC; Lew, DJ

Published Date

  • March 16, 2022

Published In

Volume / Issue

  • 86 / 1

Start / End Page

  • e0016521 -

PubMed ID

  • 35138122

Pubmed Central ID

  • PMC8826960

Electronic International Standard Serial Number (EISSN)

  • 1098-5557

Digital Object Identifier (DOI)

  • 10.1128/mmbr.00165-21

Language

  • eng

Conference Location

  • United States