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Structure-Function of TMEM16 Ion Channels and Lipid Scramblases.

Publication ,  Journal Article
Le, SC; Yang, H
Published in: Adv Exp Med Biol
2021

The TMEM16 protein family comprises two novel classes of structurally conserved but functionally distinct membrane transporters that function as Ca2+-dependent Cl- channels (CaCCs) or dual functional Ca2+-dependent ion channels and phospholipid scramblases. Extensive functional and structural studies have advanced our understanding of TMEM16 molecular mechanisms and physiological functions. TMEM16A and TMEM16B CaCCs control transepithelial fluid transport, smooth muscle contraction, and neuronal excitability, whereas TMEM16 phospholipid scramblases mediate the flip-flop of phospholipids across the membrane to allow phosphatidylserine externalization, which is essential in a plethora of important processes such as blood coagulation, bone development, and viral and cell fusion. In this chapter, we summarize the major methods in studying TMEM16 ion channels and scramblases and then focus on the current mechanistic understanding of TMEM16 Ca2+- and voltage-dependent channel gating as well as their ion and phospholipid permeation.

Duke Scholars

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2021

Volume

1349

Start / End Page

87 / 109

Location

United States

Related Subject Headings

  • Phospholipids
  • Phospholipid Transfer Proteins
  • General & Internal Medicine
  • Chloride Channels
  • Biological Transport
  • Anoctamins
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
 

Citation

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Le, S. C., & Yang, H. (2021). Structure-Function of TMEM16 Ion Channels and Lipid Scramblases. Adv Exp Med Biol, 1349, 87–109. https://doi.org/10.1007/978-981-16-4254-8_6
Le, Son C., and Huanghe Yang. “Structure-Function of TMEM16 Ion Channels and Lipid Scramblases.Adv Exp Med Biol 1349 (2021): 87–109. https://doi.org/10.1007/978-981-16-4254-8_6.
Le SC, Yang H. Structure-Function of TMEM16 Ion Channels and Lipid Scramblases. Adv Exp Med Biol. 2021;1349:87–109.
Le, Son C., and Huanghe Yang. “Structure-Function of TMEM16 Ion Channels and Lipid Scramblases.Adv Exp Med Biol, vol. 1349, 2021, pp. 87–109. Pubmed, doi:10.1007/978-981-16-4254-8_6.
Le SC, Yang H. Structure-Function of TMEM16 Ion Channels and Lipid Scramblases. Adv Exp Med Biol. 2021;1349:87–109.

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2021

Volume

1349

Start / End Page

87 / 109

Location

United States

Related Subject Headings

  • Phospholipids
  • Phospholipid Transfer Proteins
  • General & Internal Medicine
  • Chloride Channels
  • Biological Transport
  • Anoctamins
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences