RNA-mediated immunotherapy regulating tumor immune microenvironment: next wave of cancer therapeutics.

Journal Article (Journal Article;Review)

Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of tumor growth and metastasis. The cellular and molecular nature of the TIME influences cancer progression and metastasis by altering the ratio of immune- suppressive versus cytotoxic responses in the vicinity of the tumor. Targeting or activating the TIME components show a promising therapeutic avenue to combat cancer. The success of immunotherapy is both astounding and unsatisfactory in the clinic. Advancements in RNA-based technology have improved understanding of the complexity and diversity of the TIME and its effects on therapy. TIME-related RNA or RNA regulators could be promising targets for anticancer immunotherapy. In this review, we discuss the available RNA-based cancer immunotherapies targeting the TIME. More importantly, we summarize the potential of various RNA-based therapeutics clinically available for cancer treatment. RNA-dependent targeting of the TIME, as monotherapy or combined with other evolving therapeutics, might be beneficial for cancer patients' treatment in the near future.

Full Text

Duke Authors

Cited Authors

  • Pandey, PR; Young, KH; Kumar, D; Jain, N

Published Date

  • February 21, 2022

Published In

Volume / Issue

  • 21 / 1

Start / End Page

  • 58 -

PubMed ID

  • 35189921

Pubmed Central ID

  • PMC8860277

Electronic International Standard Serial Number (EISSN)

  • 1476-4598

Digital Object Identifier (DOI)

  • 10.1186/s12943-022-01528-6


  • eng

Conference Location

  • England