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Association of in-hospital depression and anxiety symptoms following stroke with 3 months- depression, anxiety and functional outcome.

Publication ,  Journal Article
Redmond, C; Bushnell, C; Duncan, P; D'Agostino, R; Ambrosius, WT; Bishop, L; Gesell, S; Prvu-Bettger, J; El Husseini, N
Published in: J Clin Neurosci
April 2022

BACKGROUND: Post-stroke depression and anxiety are common and are associated with worse post-stroke outcomes. Even though checking for depression during stroke hospitalization has become a common practice, the prognostic value of a positive in-hospital depression screen following stroke remains unclear. METHODS: This is a retrospective cohort study of patients with stroke or TIA discharged home from a tertiary care center. We examined the association between premorbid history of depression and in-hospital anxiety/depressive symptoms, with anxiety/depressive symptoms and functional outcome at 3-months post-stroke. Logistic regression models were generated using two different main predictors: 1) pre-hospital history of depression (N = 117) and 2) in-hospital depression/anxiety measured by the EQ-5D-3L (N = 66). RESULTS: In the cohort of 117 patients, the mean age was 66 years, with median NIHSS 2;44% were women and 70% White. A history of pre-stroke depression was reported by 7% (8/117). Anxiety/depression on ED-5D-3L was reported by 29/66 (43%) in the hospital and by 22/66 (33%) at three months' post-stroke. In the first adjusted model, previous history of depression was associated with 3 months EQ-5D-3L anxiety/depression (OR = 10.2;95%CI:1.12-90.9, p = 0.038). In the second adjusted model, in-hospital anxiety/depression was associated with 3-month EQ-5D-3L anxiety/depression (OR = 3.9; 95% CI:1.16-13.1, p = 0.027). In-hospital anxiety/depression was associated with a higher mRS at 3 months but not after adjusting for covariates. CONCLUSION: A previous history of depression and in-hospital anxiety/depression symptoms are associated with anxiety/depression symptoms 3-months post-stroke but not with functional outcome. Screening stroke patients for both during hospitalization is warranted because of the association with later symptoms.

Duke Scholars

Published In

J Clin Neurosci

DOI

EISSN

1532-2653

Publication Date

April 2022

Volume

98

Start / End Page

133 / 136

Location

Scotland

Related Subject Headings

  • Surveys and Questionnaires
  • Stroke
  • Retrospective Studies
  • Quality of Life
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Hospitals
  • Female
  • Depression
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Redmond, C., Bushnell, C., Duncan, P., D’Agostino, R., Ambrosius, W. T., Bishop, L., … El Husseini, N. (2022). Association of in-hospital depression and anxiety symptoms following stroke with 3 months- depression, anxiety and functional outcome. J Clin Neurosci, 98, 133–136. https://doi.org/10.1016/j.jocn.2022.02.010
Redmond, Cintasha, Cheryl Bushnell, Pamela Duncan, Ralph D’Agostino, Walter T. Ambrosius, Laura Bishop, Sabina Gesell, Janet Prvu-Bettger, and Nada El Husseini. “Association of in-hospital depression and anxiety symptoms following stroke with 3 months- depression, anxiety and functional outcome.J Clin Neurosci 98 (April 2022): 133–36. https://doi.org/10.1016/j.jocn.2022.02.010.
Redmond C, Bushnell C, Duncan P, D’Agostino R, Ambrosius WT, Bishop L, et al. Association of in-hospital depression and anxiety symptoms following stroke with 3 months- depression, anxiety and functional outcome. J Clin Neurosci. 2022 Apr;98:133–6.
Redmond, Cintasha, et al. “Association of in-hospital depression and anxiety symptoms following stroke with 3 months- depression, anxiety and functional outcome.J Clin Neurosci, vol. 98, Apr. 2022, pp. 133–36. Pubmed, doi:10.1016/j.jocn.2022.02.010.
Redmond C, Bushnell C, Duncan P, D’Agostino R, Ambrosius WT, Bishop L, Gesell S, Prvu-Bettger J, El Husseini N. Association of in-hospital depression and anxiety symptoms following stroke with 3 months- depression, anxiety and functional outcome. J Clin Neurosci. 2022 Apr;98:133–136.
Journal cover image

Published In

J Clin Neurosci

DOI

EISSN

1532-2653

Publication Date

April 2022

Volume

98

Start / End Page

133 / 136

Location

Scotland

Related Subject Headings

  • Surveys and Questionnaires
  • Stroke
  • Retrospective Studies
  • Quality of Life
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Hospitals
  • Female
  • Depression