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Managing Atherosclerotic Cardiovascular Risk in Young Adults: JACC State-of-the-Art Review.

Publication ,  Journal Article
Stone, NJ; Smith, SC; Orringer, CE; Rigotti, NA; Navar, AM; Khan, SS; Jones, DW; Goldberg, R; Mora, S; Blaha, M; Pencina, MJ; Grundy, SM
Published in: J Am Coll Cardiol
March 1, 2022

There is a need to identify high-risk features that predict early-onset atherosclerotic cardiovascular disease (ASCVD). The authors provide insights to help clinicians identify and address high-risk conditions in the 20- to 39-year age range (young adults). These include tobacco use, elevated blood pressure/hypertension, family history of premature ASCVD, primary severe hypercholesterolemia such as familial hypercholesterolemia, diabetes with diabetes-specific risk-enhancing factors, or the presence of multiple other risk-enhancing factors, including in females, a history of pre-eclampsia or menopause under age 40. The authors update current thinking on lipid risk factors such as triglycerides, non-high-density lipoprotein cholesterol, apolipoprotein B, or lipoprotein (a) that are useful in understanding an individual's long-term ASCVD risk. The authors review emerging strategies, such as coronary artery calcium and polygenic risk scores in this age group, that have potential clinical utility, but whose best use remains uncertain. Finally, the authors discuss both the obstacles and opportunities for addressing prevention in early adulthood.

Duke Scholars

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Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

March 1, 2022

Volume

79

Issue

8

Start / End Page

819 / 836

Location

United States

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Humans
  • Heart Disease Risk Factors
  • Cardiovascular System & Hematology
  • Atherosclerosis
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Stone, N. J., Smith, S. C., Orringer, C. E., Rigotti, N. A., Navar, A. M., Khan, S. S., … Grundy, S. M. (2022). Managing Atherosclerotic Cardiovascular Risk in Young Adults: JACC State-of-the-Art Review. J Am Coll Cardiol, 79(8), 819–836. https://doi.org/10.1016/j.jacc.2021.12.016
Stone, Neil J., Sidney C. Smith, Carl E. Orringer, Nancy A. Rigotti, Ann Marie Navar, Sadiya S. Khan, Daniel W. Jones, et al. “Managing Atherosclerotic Cardiovascular Risk in Young Adults: JACC State-of-the-Art Review.J Am Coll Cardiol 79, no. 8 (March 1, 2022): 819–36. https://doi.org/10.1016/j.jacc.2021.12.016.
Stone NJ, Smith SC, Orringer CE, Rigotti NA, Navar AM, Khan SS, et al. Managing Atherosclerotic Cardiovascular Risk in Young Adults: JACC State-of-the-Art Review. J Am Coll Cardiol. 2022 Mar 1;79(8):819–36.
Stone, Neil J., et al. “Managing Atherosclerotic Cardiovascular Risk in Young Adults: JACC State-of-the-Art Review.J Am Coll Cardiol, vol. 79, no. 8, Mar. 2022, pp. 819–36. Pubmed, doi:10.1016/j.jacc.2021.12.016.
Stone NJ, Smith SC, Orringer CE, Rigotti NA, Navar AM, Khan SS, Jones DW, Goldberg R, Mora S, Blaha M, Pencina MJ, Grundy SM. Managing Atherosclerotic Cardiovascular Risk in Young Adults: JACC State-of-the-Art Review. J Am Coll Cardiol. 2022 Mar 1;79(8):819–836.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

March 1, 2022

Volume

79

Issue

8

Start / End Page

819 / 836

Location

United States

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Humans
  • Heart Disease Risk Factors
  • Cardiovascular System & Hematology
  • Atherosclerosis
  • 3201 Cardiovascular medicine and haematology
  • 1117 Public Health and Health Services
  • 1102 Cardiorespiratory Medicine and Haematology