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The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection.

Publication ,  Journal Article
Harding, AT; Heaton, NS
Published in: Cancers (Basel)
February 12, 2022

Sex hormones, such as estrogen and testosterone, are steroid compounds with well-characterized effects on the coordination and development of vertebrate reproductive systems. Since their discovery, however, it has become clear that these "sex hormones" also regulate/influence a broad range of biological functions. In this review, we will summarize some current findings on how estrogens interact with and regulate inflammation and immunity. Specifically, we will focus on describing the mechanisms by which estrogens alter immune pathway activation, the impact of these changes during infection and the development of long-term immunity, and how different types of estrogens and their respective concentrations mediate these outcomes.

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Published In

Cancers (Basel)

DOI

ISSN

2072-6694

Publication Date

February 12, 2022

Volume

14

Issue

4

Location

Switzerland

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Harding, A. T., & Heaton, N. S. (2022). The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection. Cancers (Basel), 14(4). https://doi.org/10.3390/cancers14040909
Harding, Alfred T., and Nicholas S. Heaton. “The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection.Cancers (Basel) 14, no. 4 (February 12, 2022). https://doi.org/10.3390/cancers14040909.
Harding, Alfred T., and Nicholas S. Heaton. “The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection.Cancers (Basel), vol. 14, no. 4, Feb. 2022. Pubmed, doi:10.3390/cancers14040909.

Published In

Cancers (Basel)

DOI

ISSN

2072-6694

Publication Date

February 12, 2022

Volume

14

Issue

4

Location

Switzerland

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis