The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection.

Journal Article (Journal Article;Review)

Sex hormones, such as estrogen and testosterone, are steroid compounds with well-characterized effects on the coordination and development of vertebrate reproductive systems. Since their discovery, however, it has become clear that these "sex hormones" also regulate/influence a broad range of biological functions. In this review, we will summarize some current findings on how estrogens interact with and regulate inflammation and immunity. Specifically, we will focus on describing the mechanisms by which estrogens alter immune pathway activation, the impact of these changes during infection and the development of long-term immunity, and how different types of estrogens and their respective concentrations mediate these outcomes.

Full Text

Duke Authors

Cited Authors

  • Harding, AT; Heaton, NS

Published Date

  • February 12, 2022

Published In

Volume / Issue

  • 14 / 4

PubMed ID

  • 35205657

Pubmed Central ID

  • PMC8870346

International Standard Serial Number (ISSN)

  • 2072-6694

Digital Object Identifier (DOI)

  • 10.3390/cancers14040909


  • eng

Conference Location

  • Switzerland