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Checkpoint inhibitors in hematological malignancies.

Publication ,  Journal Article
Ok, CY; Young, KH
Published in: J Hematol Oncol
May 8, 2017

Inhibitory molecules such as PD-1, CTLA-4, LAG-3, or TIM-3 play a role to keep a balance in immune function. However, many cancers exploit such molecules to escape immune surveillance. Accumulating data support that their functions are dysregulated in lymphoid neoplasms, including plasma cell myeloma, myelodysplastic syndrome, and acute myeloid leukemia. In lymphoid neoplasms, aberrations in 9p24.1 (PD-L1, PD-L2, and JAK2 locus), latent Epstein-Barr virus infection, PD-L1 3'-untranslated region disruption, and constitutive JAK-STAT pathway are known mechanisms to induce PD-L1 expression in lymphoma cells. Clinical trials demonstrated that PD-1 blockade is an attractive way to restore host's immune function in hematological malignancies, particularly classical Hodgkin lymphoma. Numerous clinical trials exploring PD-1 blockade as a single therapy or in combination with other immune checkpoint inhibitors in patients with hematologic cancers are under way. Although impressive clinical response is observed with immune checkpoint inhibitors in patients with certain cancers, not all patients respond to immune checkpoint inhibitors. Therefore, to identify best candidates who would have excellent response to checkpoint inhibitors is of utmost importance. Several possible biomarkers are available, but consensus has not been made and pursuit to discover the best biomarker is ongoing.

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Published In

J Hematol Oncol

DOI

EISSN

1756-8722

Publication Date

May 8, 2017

Volume

10

Issue

1

Start / End Page

103

Location

England

Related Subject Headings

  • Tumor Escape
  • Programmed Cell Death 1 Receptor
  • Patient Selection
  • Neoplasm Proteins
  • Multicenter Studies as Topic
  • Molecular Targeted Therapy
  • Lymphocyte Activation Gene 3 Protein
  • Lymphocyte Activation
  • Humans
  • Hepatitis A Virus Cellular Receptor 2
 

Citation

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Ok, C. Y., & Young, K. H. (2017). Checkpoint inhibitors in hematological malignancies. J Hematol Oncol, 10(1), 103. https://doi.org/10.1186/s13045-017-0474-3
Ok, Chi Young, and Ken H. Young. “Checkpoint inhibitors in hematological malignancies.J Hematol Oncol 10, no. 1 (May 8, 2017): 103. https://doi.org/10.1186/s13045-017-0474-3.
Ok CY, Young KH. Checkpoint inhibitors in hematological malignancies. J Hematol Oncol. 2017 May 8;10(1):103.
Ok, Chi Young, and Ken H. Young. “Checkpoint inhibitors in hematological malignancies.J Hematol Oncol, vol. 10, no. 1, May 2017, p. 103. Pubmed, doi:10.1186/s13045-017-0474-3.
Ok CY, Young KH. Checkpoint inhibitors in hematological malignancies. J Hematol Oncol. 2017 May 8;10(1):103.
Journal cover image

Published In

J Hematol Oncol

DOI

EISSN

1756-8722

Publication Date

May 8, 2017

Volume

10

Issue

1

Start / End Page

103

Location

England

Related Subject Headings

  • Tumor Escape
  • Programmed Cell Death 1 Receptor
  • Patient Selection
  • Neoplasm Proteins
  • Multicenter Studies as Topic
  • Molecular Targeted Therapy
  • Lymphocyte Activation Gene 3 Protein
  • Lymphocyte Activation
  • Humans
  • Hepatitis A Virus Cellular Receptor 2