Immune checkpoint blockade: Releasing the brake towards hematological malignancies.
Journal Article (Journal Article;Review)
Tumor cells utilize co-inhibitory molecules to avoid host immune destruction. Checkpoint blockade has emerged as a promising approach to treat cancer by restoring T cell effector function and breaking a tumor permissive microenvironment. Patients with hematological malignancies often have immune dysregulation, thus the role of checkpoint blockade in treatment of these neoplasms is particularly intriguing. In early trials, antibodies targeting cytotoxic T lymphocyte antigen 4 (CTLA-4) or the programmed death 1 (PD-1) signaling pathway have displayed significant efficacy with minimal toxicity in patients with relapsed and refractory hematological neoplasms. In this review, we provide evidence of dysregulation of CTLA-4 and PD-1/PD-Ls in the context of several major types of hematological neoplasms and summarize relevant clinical practice points for checkpoint blockade. The preclinical rationale and preliminary clinical data of potential combination approaches designed to optimize checkpoint antagonists are well presented.
Full Text
Duke Authors
Cited Authors
- Xia, Y; Medeiros, LJ; Young, KH
Published Date
- May 2016
Published In
Volume / Issue
- 30 / 3
Start / End Page
- 189 - 200
PubMed ID
- 26699946
Electronic International Standard Serial Number (EISSN)
- 1532-1681
Digital Object Identifier (DOI)
- 10.1016/j.blre.2015.11.003
Language
- eng
Conference Location
- England