Atypical chronic myeloid leukemia is clinically distinct from unclassifiable myelodysplastic/myeloproliferative neoplasms.

Journal Article (Journal Article)

Atypical chronic myeloid leukemia (aCML) is a rare subtype of myelodysplastic/myeloproliferative neoplasm (MDS/MPN) largely defined morphologically. It is, unclear, however, whether aCML-associated features are distinctive enough to allow its separation from unclassifiable MDS/MPN (MDS/MPN-U). To study these 2 rare entities, 134 patient archives were collected from 7 large medical centers, of which 65 (49%) cases were further classified as aCML and the remaining 69 (51%) as MDS/MPN-U. Distinctively, aCML was associated with many adverse features and an inferior overall survival (12.4 vs 21.8 months, P = .004) and AML-free survival (11.2 vs 18.9 months, P = .003). The aCML defining features of leukocytosis and circulating myeloid precursors, but not dysgranulopoiesis, were independent negative predictors. Other factors, such as lactate dehydrogenase, circulating myeloblasts, platelets, and cytogenetics could further stratify MDS/MPN-U but not aCML patient risks. aCML appeared to have more mutated RAS (7/20 [35%] vs 4/29 [14%]) and less JAK2p.V617F (3/42 [7%] vs 10/52 [19%]), but was not statistically significant. Somatic CSF3R T618I (0/54) and CALR (0/30) mutations were not detected either in aCML or MDS/MPN-U. In conclusion, within MDS/MPN, the World Health Organization 2008 criteria for aCML identify a subgroup of patients with features clearly distinct from MDS/MPN-U. The MDS/MPN-U category is heterogeneous, and patient risk can be further stratified by a number of clinicopathological parameters.

Full Text

Duke Authors

Cited Authors

  • Wang, SA; Hasserjian, RP; Fox, PS; Rogers, HJ; Geyer, JT; Chabot-Richards, D; Weinzierl, E; Hatem, J; Jaso, J; Kanagal-Shamanna, R; Stingo, FC; Patel, KP; Mehrotra, M; Bueso-Ramos, C; Young, KH; Dinardo, CD; Verstovsek, S; Tiu, RV; Bagg, A; Hsi, ED; Arber, DA; Foucar, K; Luthra, R; Orazi, A

Published Date

  • April 24, 2014

Published In

Volume / Issue

  • 123 / 17

Start / End Page

  • 2645 - 2651

PubMed ID

  • 24627528

Pubmed Central ID

  • PMC4067498

Electronic International Standard Serial Number (EISSN)

  • 1528-0020

Digital Object Identifier (DOI)

  • 10.1182/blood-2014-02-553800


  • eng

Conference Location

  • United States